MMP9 (基因名), Matrix metalloproteinase-9 (蛋白名), MMP9_HUMAN.
Human MMP9/ Matrix metalloproteinase-9 Recombinant Protein
92 kDa gelatinase, 92 kDa type IV collagenase, Gelatinase B, GELB, MMP-9, CLG4B
17.6 kDa (monomer)
Greater than 98% by SDS-PAGE
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50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
Store at -20°C. (Avoid repeated freezing and thawing.)
The PCR product of human MMP9 gene was determined by 1% Agarose stained with EB.
Recombinant human MMP9 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
Exists as monomer or homodimer; disulfide-linked. Exists also as heterodimer with a 25 kDa protein. Macrophages and transformed cell lines produce only the monomeric form. Interacts with ECM1.
May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.
Secreted Extracellular space Extracellular matrix
MSLWQPLVLV | LLVLGCCFAA | PRQRQSTLVL | FPGDLRTNLT | DRQLAEEYLY |
RYGYTRVAEM | RGESKSLGPA | LLLLQKQLSL | PETGELDSAT | LKAMRTPRCG |
VPDLGRFQTF | EGDLKWHHHN | ITYWIQNYSE | DLPRAVIDDA | FARAFALWSA |
VTPLTFTRVY | SRDADIVIQF | GVAEHGDGYP | FDGKDGLLAH | AFPPGPGIQG |
DAHFDDDELW | SLGKGVVVPT | RFGNADGAAC | HFPFIFEGRS | YSACTTDGRS |
DGLPWCSTTA | NYDTDDRFGF | CPSERLYTQD | GNADGKPCQF | PFIFQGQSYS |
ACTTDGRSDG | YRWCATTANY | DRDKLFGFCP | TRADSTVMGG | NSAGELCVFP |
FTFLGKEYST | CTSEGRGDGR | LWCATTSNFD | SDKKWGFCPD | QGYSLFLVAA |
HEFGHALGLD | HSSVPEALMY | PMYRFTEGPP | LHKDDVNGIR | HLYGPRPEPE |
PRPPTTTTPQ | PTAPPTVCPT | GPPTVHPSER | PTAGPTGPPS | AGPTGPPTAG |
PSTATTVPLS | PVDDACNVNI | FDAIAEIGNQ | LYLFKDGKYW | RFSEGRGSRP |
QGPFLIADKW | PALPRKLDSV | FEERLSKKLF | FFSGRQVWVY | TGASVLGPRR |
LDKLGLGADV | AQVTGALRSG | RGKMLLFSGR | RLWRFDVKAQ | MVDPRSASEV |
DRMFPGVPLD | THDVFQYREK | AYFCQDRFYW | RVSSRSELNQ | VDQVGYVTYD |
"Erythropoietin attenuates ischemia–reperfusion induced lung injury by inhibiting tumor necrosis factor-α and matrix metalloproteinase-9 expression"
Haiwei Wu, Guohua Dong, Hao Liu, Biao Xu, Demin Li, Hua Jing
J Šímová, J Škvor, D Slovák, et al.
From: Folia Biologica (Praha)
"Association of matrix metalloproteinase 9 genotypes and cardiovascular disease risk factors with serum matrix metalloproteinase 9 concentrations in Taiwanese individuals."
"A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation."
"Promoter polymorphisms in matrix metalloproteinases and their inhibitors: few associations with breast cancer susceptibility and progression."
"Influence of MMP-2 and MMP-9 promoter polymorphisms on gene expression and clinical outcome of non-small cell lung cancer."
"Analysis of MMP-1 and MMP-9 promoter polymorphisms in early osseointegrated implant failure."
"Matrix metalloproteinase 9 (MMP-9) gene polymorphism and MMP-9 plasma levels in primary Sjogren's syndrome."
"Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection."
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."
"A Large-scale genetic association study of esophageal adenocarcinoma risk."
"Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease."
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