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MMP9 (基因名), Matrix metalloproteinase-9 (蛋白名), MMP9_HUMAN.
产品名称:

Human MMP9/ Matrix metalloproteinase-9 Recombinant Protein
矩阵metalloproteinase-9

货号:

R0553h

商标:
EIAab®
监管等级:
别名:

92 kDa gelatinase, 92 kDa type IV collagenase, Gelatinase B, GELB, MMP-9, CLG4B

序列号:
P14780
来源:
E.coli
种属:
Human
标签:
His
序列:
161-320aa
预估分子量:
17.6 kDa (monomer)
纯度:
Greater than 98% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
  • Human MMP9 Protein
  • Human MMP9 Protein
  • Human MMP9 Protein
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Human MMP9 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


R&D 技术数据
Human MMP9 Protein
The PCR product of human MMP9 gene was determined by 1% Agarose stained with EB.
Human MMP9 Protein
Recombinant human MMP9 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 20q13.12 by HGNC 20q13.12 by Entrez Gene 20q13.12 by Ensembl
MMP9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Exists as monomer or homodimer; disulfide-linked. Exists also as heterodimer with a 25 kDa protein. Macrophages and transformed cell lines produce only the monomeric form. Interacts with ECM1.


功能:
May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.


亚细胞位置:
Secreted Extracellular space Extracellular matrix



[1].
"Association of matrix metalloproteinase 9 genotypes and cardiovascular disease risk factors with serum matrix metalloproteinase 9 concentrations in Taiwanese individuals."

[2].
"A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation."

[3].
"Promoter polymorphisms in matrix metalloproteinases and their inhibitors: few associations with breast cancer susceptibility and progression."

[4].
"Influence of MMP-2 and MMP-9 promoter polymorphisms on gene expression and clinical outcome of non-small cell lung cancer."

[5].
"Analysis of MMP-1 and MMP-9 promoter polymorphisms in early osseointegrated implant failure."

[6].
"Matrix metalloproteinase 9 (MMP-9) gene polymorphism and MMP-9 plasma levels in primary Sjogren's syndrome."

[7].
"Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection."

[8].
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

[9].
"A Large-scale genetic association study of esophageal adenocarcinoma risk."

[10].
"Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease."
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