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Mmp2 (基因名), 72 kDa type IV collagenase (蛋白名), MMP2_RAT.
产品名称:

Rat Mmp2/ 72 kDa type IV collagenase Recombinant Protein
基质金属蛋白酶2/明胶酶A

货号:

R0100r

商标:
EIAab®
监管等级:
别名:

72 kDa gelatinase, Gelatinase A, Matrix metalloproteinase-2, MMP-2

序列号:
P33436
来源:
E.coli
种属:
Rat
标签:
His
序列:
30-109aa
预估分子量:
8.8 kDa (monomer)
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Rat Mmp2 Protein
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Rat Mmp2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
通用注释


亚单元:
Interacts (via the C-terminal hemopexin-like domains-containing region) with the integrin alpha-V/beta-3; the interaction promotes vascular invasion in angiogenic vessels and melamoma cells. Interacts (via the C-terminal PEX domain) with TIMP2 (via the C-terminal); the interaction inhibits the degradation activity. Interacts with GSK3B.


功能:
PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrin alpha-v/beta3 on the surface of blood vessels.


亚细胞位置:
Secreted Extracellular space Extracellular matrix Membrane Nucleus Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas. Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes (By similarity).


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