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MMP24 (基因名), Matrix metalloproteinase-24 (蛋白名), MMP24_HUMAN.
产品名称:

Human MMP24/ Matrix metalloproteinase-24 Recombinant Protein
矩阵metalloproteinase-24

货号:

R0555h

商标:
EIAab®
监管等级:
别名:

Membrane-type matrix metalloproteinase 5, Membrane-type-5 matrix metalloproteinase, MT-MMP 5, MT5-MMP, MMP-24, MT5MMP

序列号:
Q9Y5R2
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human MMP24 Protein
规格 & 价格: cart
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Human MMP24 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 20q11.22 by HGNC 20q11.22 by Entrez Gene 20q11.22 by Ensembl
MMP24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts (via PDZ-binding motif) with APBA3 (via PDZ domain). Interacts with GRIP1 and GRIP2.


功能:
Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin.


亚细胞位置:
Processed matrix metalloproteinase-24 Secreted Extracellular space Extracellular matrix Also shed from cell surface as soluble proteinase, by a proteolytic cleavage.


该产品尚未在任何出版物中被引用。

[1].
"Identification and characterization of human MT5-MMP, a new membrane-bound activator of progelatinase a overexpressed in brain tumors."

[2].
"Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection."

[3].
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

[4].
"The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature."

[5].
"Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies."

[6].
"Many sequence variants affecting diversity of adult human height."

[7].
"Expression of membrane-type 5 matrix metalloproteinase in human endometrium and endometriosis."

[8].
"Identification of a novel human MT5-MMP transcript variant in multipotent NT2 cells."

[9].
"Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases."

[10].
"The DNA sequence and comparative analysis of human chromosome 20."
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