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MMP1 (基因名), Interstitial collagenase (蛋白名), MMP1_HUMAN.
产品名称:

Human MMP1/ Interstitial collagenase Recombinant Protein
间质胶原

货号:

R0097h

商标:
EIAab®
监管等级:
别名:

Fibroblast collagenase, Matrix metalloproteinase-1, MMP-1, CLG

序列号:
P03956
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Human MMP1 Protein
规格 & 价格: cart
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Human MMP1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 11q22.2 by HGNC 11q22.2 by Entrez Gene 11q22.2 by Ensembl
MMP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with HIV-1 Tat.


功能:
Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X (PubMed:2557822, PubMed:2153297, PubMed:1645757). In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity (PubMed:16807369).


亚细胞位置:
Secreted Extracellular space Extracellular matrix



[1].
"Genome-wide association scan identifies variants near Matrix Metalloproteinase (MMP) genes on chromosome 11q21-22 strongly associated with serum MMP-1 levels."

[2].
"Analysis of germline variants in CDH1, IGFBP3, MMP1, MMP3, STK15 and VEGF in familial and sporadic renal cell carcinoma."

[3].
"Gene polymorphisms related to angiogenesis, inflammation and thrombosis that influence risk for oral cancer."

[4].
"Clinical significance of a single nucleotide polymorphism and allelic imbalance of matrix metalloproteinase-1 promoter region in prostate cancer."

[5].
"Association between promoter -1607 polymorphism of MMP1 and lumbar disc disease in Southern Chinese."

[6].
"Genetic and epigenetic mechanisms combine to control MMP1 expression and its association with preterm premature rupture of membranes."

[7].
"Matrix metalloproteinase-1 gene polymorphism in renal transplant patients with and without gingival enlargement."

[8].
"A functional polymorphism in the matrix metalloproteinase-1 gene promoter is associated with susceptibility and aggressiveness of head and neck cancer."

[9].
"Polymorphisms of the promoter regions of matrix metalloproteinases genes MMP-1 and MMP-9 in breast cancer."

[10].
"A polymorphism in the matrix metalloproteinase-1 gene promoter is associated with the prognosis of patients with ovarian cancer."
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