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MMP13 (基因名), Collagenase 3 (蛋白名), MMP13_HUMAN.
产品名称:

Human MMP13/ Collagenase 3 Recombinant Protein
胶原蛋白酶3

货号:

R0099h

商标:
EIAab®
监管等级:
别名:

Matrix metalloproteinase-13, MMP-13

序列号:
P45452
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Human MMP13 Protein
规格 & 价格: cart
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Human MMP13 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 11q22.2 by HGNC 11q22.2 by Entrez Gene 11q22.2 by Ensembl
MMP13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Monomer. Interacts with TIMP1, TIMP2 and TIMP3. Binds (via the C-terminal region) to collagen.


功能:
Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.


亚细胞位置:
Secreted Extracellular space Extracellular matrix Secreted



[1].
"Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects."

[2].
"MMP13 mutation causes spondyloepimetaphyseal dysplasia, Missouri type (SEMD(MO)."

[3].
"MMP13 promoter polymorphism is associated with atherosclerosis in the abdominal aorta of young black males."

[4].
"A matrix metalloproteinase gene expressed in human T lymphocytes is identical with collagenase 3 from breast carcinomas."

[5].
"Biochemical characterization of human collagenase-3."
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