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MMP12 (基因名), Macrophage metalloelastase (蛋白名), MMP12_HUMAN.
产品名称:

Human MMP12/ Macrophage metalloelastase Recombinant Protein
巨噬细胞金属弹力

货号:

R0402h

商标:
EIAab®
监管等级:
别名:

Macrophage elastase, Matrix metalloproteinase-12, ME, MMP-12, MME, HME

序列号:
P39900
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Human MMP12 Protein
规格 & 价格: cart
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Human MMP12 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 11q22.2 by HGNC 11q22.2 by Entrez Gene 11q22.2 by Ensembl
MMP12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
N/A


功能:
May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.


亚细胞位置:
Secreted Extracellular space Extracellular matrix



[1].
"[Association of functional polymorphisms on MMP-12 and MMP-13 gene promoter region with epithelial ovarian carcinoma]."

[2].
"The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function."

[3].
"Substrate specificity determinants of human macrophage elastase (MMP-12) based on the 1.1 A crystal structure."

[4].
"Crystal structure of human macrophage elastase (MMP-12) in complex with a hydroxamic acid inhibitor."

[5].
"Hydrolysis of a broad spectrum of extracellular matrix proteins by human macrophage elastase."

[6].
"Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages."

[7].
"Association of functional polymorphisms in MMPs genes with gastric cardia adenocarcinoma and esophageal squamous cell carcinoma in high incidence region of North China."

[8].
"Single nucleotide polymorphisms in matrix metalloproteinase genes and lung cancer chemotherapy response and prognosis."

[9].
"MMP-12 catalytic domain recognizes and cleaves at multiple sites in human skin collagen type I and type III."

[10].
"Association of MMP-2 polymorphisms with severe and very severe COPD: a case control study of MMPs-1, 9 and 12 in a European population."
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