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MLX (基因名), Max-like protein X (蛋白名), MLX_HUMAN.
产品名称:

Human MLX/ Max-like protein X Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Class D basic helix-loop-helix protein 13, Max-like bHLHZip protein, Protein BigMax, Transcription factor-like protein 4, bHLHd13, BHLHD13, TCFL4

序列号:
Q9UH92
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human MLX Protein
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Human MLX Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


基因位点
Cytogenetic band: 17q21.1 by HGNC 17q21.1 by Entrez Gene 17q21.1 by Ensembl
MLX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAD1, MAD4, MNT, WBSCR14 and MLXIP. Can also bind DNA as a homodimer.


功能:
Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.


亚细胞位置:
Isoform Gamma Nucleus Found predominantly in the nucleus (PubMed:10918583).


该产品尚未在任何出版物中被引用。

[1].
"Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?"

[2].
"Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors."

[3].
"TCFL4: a gene at 17q21.1 encoding a putative basic helix-loop-helix leucine-zipper transcription factor."

[4].
"Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression."

[5].
"MondoA-Mlx heterodimers are candidate sensors of cellular energy status: mitochondrial localization and direct regulation of glycolysis."

[6].
"Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes."

[7].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."

[8].
"The subcellular localization of the ChoRE-binding protein, encoded by the Williams-Beuren syndrome critical region gene 14, is regulated by 14-3-3."

[9].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[10].
"A novel heterodimerization domain, CRM1, and 14-3-3 control subcellular localization of the MondoA-Mlx heterocomplex."
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