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MLXIP (基因名), MLX-interacting protein (蛋白名), MLXIP_HUMAN.
产品名称:

Human MLXIP/ MLX-interacting protein Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Class E basic helix-loop-helix protein 36, Transcriptional activator MondoA, bHLHe36, BHLHE36, KIAA0867, MIR, MONDOA

序列号:
Q9HAP2
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human MLXIP Protein
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Human MLXIP Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


基因位点
Cytogenetic band: 12q21.31 by HGNC 12q21.31 by Entrez Gene 12q21.31 by Ensembl
MLXIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer with MLX.


功能:
Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.


亚细胞位置:
Cytoplasm Nucleus Mitochondrion outer membrane Predominantly cytoplasmic but shuttles between cytoplasm and nucleus when associated with MLX. Also associates with the outer mitochondrial membrane and may shuttle between the outer mitochondrial membrane and the nucleus.


该产品尚未在任何出版物中被引用。

[1].
"MondoA, a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network."

[2].
"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."

[3].
"Glutamine-dependent anapleurosis dictates glucose uptake and cell growth by regulating MondoA transcriptional activity."

[4].
"Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression."

[5].
"MondoA-Mlx heterodimers are candidate sensors of cellular energy status: mitochondrial localization and direct regulation of glycolysis."

[6].
"A novel heterodimerization domain, CRM1, and 14-3-3 control subcellular localization of the MondoA-Mlx heterocomplex."

[7].
"MondoA Is an Essential Glucose-Responsive Transcription Factor in Human Pancreatic β-Cells."

[8].
"Architecture of the human interactome defines protein communities and disease networks."

[9].
"MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling."

[10].
"Contrasting Patterns in the Evolution of Vertebrate MLX Interacting Protein (MLXIP) and MLX Interacting Protein-Like (MLXIPL) Genes."
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