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首页  >  重组蛋白  >  Human MYL2 Recombinant Protein
MYL2 (基因名), Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (蛋白名), MLRV_HUMAN.
产品名称:

Human MYL2/ Myosin regulatory light chain 2, ventricular/cardiac muscle isoform Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Cardiac myosin light chain 2, Myosin light chain 2, slow skeletal/ventricular muscle isoform, Ventricular myosin light chain 2, MLC-2s/v, MLC-2, MLC2

序列号:
P10916
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human MYL2 Protein
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Human MYL2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


基因位点
Cytogenetic band: 12q24.11 by HGNC 12q24.11 by Entrez Gene 12q24.11 by Ensembl
MYL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Myosin is a hexamer of 2 heavy chains and 4 light chains. Interacts with MYOC (PubMed:11773029).


功能:
Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly.


亚细胞位置:
Cytoplasm Myofibril Sarcomere A band


该产品尚未在任何出版物中被引用。

[1].
"The role of sarcomere gene mutations in patients with idiopathic dilated cardiomyopathy."

[2].
"Systematic analysis of the regulatory and essential myosin light chain genes: genetic variants and mutations in hypertrophic cardiomyopathy."

[3].
"Identification of two novel mutations in the ventricular regulatory myosin light chain gene (MYL2) associated with familial and classical forms of hypertrophic cardiomyopathy."

[4].
"Interaction of a conserved peptide domain in recombinant human ventricular myosin light chain-2 with myosin heavy chain."

[5].
"Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits."

[6].
"Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men."

[7].
"Clinical features and outcome of hypertrophic cardiomyopathy associated with triple sarcomere protein gene mutations."

[8].
"Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia."

[9].
"Histologic characterization of hypertrophic cardiomyopathy with and without myofilament mutations."

[10].
"The role of Lamin A/C mutations in Danish patients with idiopathic dilated cardiomyopathy."
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