MYL2 (基因名), Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (蛋白名), MLRV_HUMAN.
Human MYL2/ Myosin regulatory light chain 2, ventricular/cardiac muscle isoform Recombinant Protein
Cardiac myosin light chain 2, Myosin light chain 2, slow skeletal/ventricular muscle isoform, Ventricular myosin light chain 2, MLC-2s/v, MLC-2, MLC2
>90% by SDS-PAGE
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50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
Store at -20°C. (Avoid repeated freezing and thawing.)
Myosin is a hexamer of 2 heavy chains and 4 light chains. Interacts with MYOC (PubMed:11773029).
Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly.
Cytoplasm Myofibril Sarcomere A band
MAPKKAKKRA | GGANSNVFSM | FEQTQIQEFK | EAFTIMDQNR | DGFIDKNDLR |
DTFAALGRVN | VKNEEIDEMI | KEAPGPINFT | VFLTMFGEKL | KGADPEETIL |
NAFKVFDPEG | KGVLKADYVR | EMLTTQAERF | SKEEVDQMFA | AFPPDVTGNL |
DYKNLVHIIT | HGEEKD
"The role of sarcomere gene mutations in patients with idiopathic dilated cardiomyopathy."
"Systematic analysis of the regulatory and essential myosin light chain genes: genetic variants and mutations in hypertrophic cardiomyopathy."
"Identification of two novel mutations in the ventricular regulatory myosin light chain gene (MYL2) associated with familial and classical forms of hypertrophic cardiomyopathy."
"Interaction of a conserved peptide domain in recombinant human ventricular myosin light chain-2 with myosin heavy chain."
"Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits."
"Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men."
"Clinical features and outcome of hypertrophic cardiomyopathy associated with triple sarcomere protein gene mutations."
"Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia."
"Histologic characterization of hypertrophic cardiomyopathy with and without myofilament mutations."
"The role of Lamin A/C mutations in Danish patients with idiopathic dilated cardiomyopathy."
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