EIAab
首页  >  重组蛋白  >  Human MLF1 Recombinant Protein
MLF1 (基因名), Myeloid leukemia factor 1 (蛋白名), MLF1_HUMAN.
产品名称:

Human MLF1/ Myeloid leukemia factor 1 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Myelodysplasia-myeloid leukemia factor 1

序列号:
P58340
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Human MLF1 Protein
×
Human MLF1 Protein
邮箱 *
消息 *
Please 登录.
产品说明书
说明书: 下载说明书
MSDS: MSDS


基因位点
Cytogenetic band: 3q25.32 by HGNC 3q25.32 by Entrez Gene 3q25.32 by Ensembl
MLF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with CENPU. Also interacts with NRBP1/MADM, YWHAZ/14-3-3-zeta and HNRPUL2/MANP. NRBP1 recruits a serine kinase which phosphorylates both itself and MLF1. Phosphorylated MLF1 then binds to YWHAZ and is retained in the cytoplasm. Retained in the nucleus by binding to HNRPUL2. Binds to COPS3/CSN3 which is required for suppression of RFWD2 and activation of p53.


功能:
Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.


亚细胞位置:
Cytoplasm Nucleus Shuttles between the cytoplasm and nucleus.


该产品尚未在任何出版物中被引用。

[1].
"The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1."

[2].
"Myeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3."

[3].
"Structural insights of the MLF1/14-3-3 interaction."

[4].
"Detection of t(3;5) and NPM1/MLF1 rearrangement in an elderly patient with acute myeloid leukemia: clinical and laboratory study with review of the literature."

[5].
"Gene variants associated with ischemic stroke: the cardiovascular health study."

[6].
"Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study."

[7].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."

[8].
"cDNA cloning and characterization of a novel gene encoding the MLF1-interacting protein MLF1IP."

[9].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[10].
"Detection of NPM/MLF1 fusion in t(3;5)-positive acute myeloid leukemia and myelodysplasia."
关闭
Sample Data
关闭
Sample Data
关闭
Sample Data
用户中心 close
购物车 close
我的收藏 close
我的足迹 close
清除
产品对比 close
用户中心
购物车
我的收藏
我的足迹
产品对比
回到顶部
消息
close_message
产品名称 *
邮箱 *
消息 *
通知
new 留 言
规格 数量 单价 (¥) 小计 1 (¥)
小计 2:
triangle
规格 数量 单价 (¥)
你想做我们的代理并得到更低的折扣吗?
请联系我们:
电话:027-59234612(+86)
传真:027-59234610(+86)
邮箱:sales@eiaab.com