MDK (基因名), Midkine (蛋白名), MK_HUMAN.
Human MDK/ Midkine Recombinant Protein
Amphiregulin-associated protein, Midgestation and kidney protein, Neurite outgrowth-promoting factor 2, Neurite outgrowth-promoting protein, ARAP, MK, MK1, NEGF2
13.53 kDa (monomer)
Greater than 95% by SDS-PAGE
Please contact email@example.com The technician for more information.
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
Store at -20°C. (Avoid repeated freezing and thawing.)
Homodimer. Interacts with ALK.
Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development.
"COMPARATIVE STUDY BETWEEN DKK-1 AND AFP FOR DIAGNOSING OF HEPATOCELLULAR CARCINOMA AMONG EGYPTIAN PATIENTS"
Mohamed F Z, Barakat L A A, Radwan N H, et al.
"Midkine gene (MDK), a gene for prenatal differentiation and neuroregulation, maps to band 11p11.2 by fluorescence in situ hybridization."
"Cloning, characterization and developmental regulation of two members of a novel human gene family of neurite outgrowth-promoting proteins."
"Amphiregulin-associated protein: complete amino acid sequence of a protein produced by the 12-0-tetradecanoylphorbol-13-acetate-treated human breast adenocarcinoma cell line MCF-7."
"Midkine positively regulates the proliferation of human gastric cancer cells."
"[Relationship between midkine expression and drug efflux in childhood acute lymphoblastic leukemia cells]."
"The angiogenic factor midkine is regulated by dexamethasone and retinoic acid during alveolarization and in alveolar epithelial cells."
"Midkine prevents ventricular remodeling and improves long-term survival after myocardial infarction."
"Midkine promotes tetraspanin-integrin interaction and induces FAK-Stat1alpha pathway contributing to migration/invasiveness of human head and neck squamous cell carcinoma cells."
"Midkine as a prognostic biomarker in oral squamous cell carcinoma."
"Impact of alcohol abuse on protein expression of midkine and excitatory amino acid transporter 1 in the human prefrontal cortex."
评论数 : 0
规格 数量 单价 (￥) 小计 1 (￥)
小计 2: ￥
规格 数量 单价 (￥)