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MDK (基因名), Midkine (蛋白名), MK_HUMAN.
产品名称:

Human MDK/ Midkine Recombinant Protein
肝素结合细胞因子

货号:

R0631h

商标:
EIAab®
监管等级:
别名:

Amphiregulin-associated protein, Midgestation and kidney protein, Neurite outgrowth-promoting factor 2, Neurite outgrowth-promoting protein, ARAP, MK, MK1, NEGF2

序列号:
P21741
来源:
E.coli
种属:
Human
标签:
His
序列:
21-143aa
预估分子量:
13.53 kDa (monomer)
纯度:
Greater than 95% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Neurosciences
Human MDK Protein
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Human MDK Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 11p11.2 by HGNC 11p11.2 by Entrez Gene 11p11.2 by Ensembl
MDK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homodimer. Interacts with ALK.


功能:
Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development.


亚细胞位置:
Secreted



[1].
"Midkine gene (MDK), a gene for prenatal differentiation and neuroregulation, maps to band 11p11.2 by fluorescence in situ hybridization."

[2].
"Cloning, characterization and developmental regulation of two members of a novel human gene family of neurite outgrowth-promoting proteins."

[3].
"Amphiregulin-associated protein: complete amino acid sequence of a protein produced by the 12-0-tetradecanoylphorbol-13-acetate-treated human breast adenocarcinoma cell line MCF-7."

[4].
"Midkine positively regulates the proliferation of human gastric cancer cells."

[5].
"[Relationship between midkine expression and drug efflux in childhood acute lymphoblastic leukemia cells]."

[6].
"The angiogenic factor midkine is regulated by dexamethasone and retinoic acid during alveolarization and in alveolar epithelial cells."

[7].
"Midkine prevents ventricular remodeling and improves long-term survival after myocardial infarction."

[8].
"Midkine promotes tetraspanin-integrin interaction and induces FAK-Stat1alpha pathway contributing to migration/invasiveness of human head and neck squamous cell carcinoma cells."

[9].
"Midkine as a prognostic biomarker in oral squamous cell carcinoma."

[10].
"Impact of alcohol abuse on protein expression of midkine and excitatory amino acid transporter 1 in the human prefrontal cortex."
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