EIAab
首页  >  重组蛋白  >  Human MKRN1 Recombinant Protein
MKRN1 (基因名), E3 ubiquitin-protein ligase makorin-1 (蛋白名), MKRN1_HUMAN.
产品名称:

Human MKRN1/ E3 ubiquitin-protein ligase makorin-1 Recombinant Protein

货号:

R16028h

商标:
EIAab®
监管等级:
别名:

RING finger protein 61, RING-type E3 ubiquitin transferase makorin-1, RNF61

序列号:
Q9UHC7
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human MKRN1 Protein
规格 & 价格: cart
×
Human MKRN1 Protein
邮箱 *
消息 *
Please 登录.
产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 7q34 by HGNC 7q34 by Entrez Gene 7q34 by Ensembl
MKRN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with p53/TP53 and CDKN1A. Interacts with TERT, modulating telomere length homeostasis.


功能:
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription.


亚细胞位置:
N/A


该产品尚未在任何出版物中被引用。

[1].
"The ancient source of a distinct gene family encoding proteins featuring RING and C(3)H zinc-finger motifs with abundant expression in developing brain and nervous system."

[2].
"Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis."

[3].
"Identification of Makorin 1 as a novel SEREX antigen of esophageal squamous cell carcinoma."

[4].
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."

[5].
"Makorin RING finger protein 1 (MKRN1) has negative and positive effects on RNA polymerase II-dependent transcription."

[6].
"Ubiquitin ligase MKRN1 modulates telomere length homeostasis through a proteolysis of hTERT."

[7].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[8].
"Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."

[9].
"Human Adenovirus Infection Causes Cellular E3 Ubiquitin Ligase MKRN1 Degradation Involving the Viral Core Protein pVII."

[10].
"Architecture of the human interactome defines protein communities and disease networks."
关闭
Sample Data
关闭
Sample Data
关闭
Sample Data
用户中心 close
购物车 close
我的收藏 close
我的足迹 close
清除
产品对比 close
用户中心
购物车
我的收藏
我的足迹
产品对比
回到顶部
通知
new 咨询
规格 数量 单价 (¥) 小计 1 (¥)
小计 2:
triangle
规格 数量 单价 (¥)
你想做我们的代理并得到更低的折扣吗?
请联系我们:
电话:027-59234612(+86)
传真:027-59234610(+86)
邮箱:sales@eiaab.com