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MKRN1 (基因名), E3 ubiquitin-protein ligase makorin-1 (蛋白名), MKRN1_HUMAN.
产品名称:

Human MKRN1/ E3 ubiquitin-protein ligase makorin-1 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

RING finger protein 61, RING-type E3 ubiquitin transferase makorin-1, RNF61

序列号:
Q9UHC7
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human MKRN1 Protein
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Human MKRN1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


基因位点
Cytogenetic band: 7q34 by HGNC 7q34 by Entrez Gene 7q34 by Ensembl
MKRN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with p53/TP53 and CDKN1A. Interacts with TERT, modulating telomere length homeostasis.


功能:
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription.


亚细胞位置:
N/A


该产品尚未在任何出版物中被引用。

[1].
"The ancient source of a distinct gene family encoding proteins featuring RING and C(3)H zinc-finger motifs with abundant expression in developing brain and nervous system."

[2].
"Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis."

[3].
"Identification of Makorin 1 as a novel SEREX antigen of esophageal squamous cell carcinoma."

[4].
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."

[5].
"Makorin RING finger protein 1 (MKRN1) has negative and positive effects on RNA polymerase II-dependent transcription."

[6].
"Ubiquitin ligase MKRN1 modulates telomere length homeostasis through a proteolysis of hTERT."

[7].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[8].
"Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."

[9].
"Human Adenovirus Infection Causes Cellular E3 Ubiquitin Ligase MKRN1 Degradation Involving the Viral Core Protein pVII."

[10].
"Architecture of the human interactome defines protein communities and disease networks."
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