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MKNK2 (基因名), MAP kinase-interacting serine/threonine-protein kinase 2 (蛋白名), MKNK2_HUMAN.
产品名称:

Human MKNK2/ MAP kinase-interacting serine/threonine-protein kinase 2 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

MAP kinase signal-integrating kinase 2, MAPK signal-integrating kinase 2, GPRK7, MNK2

序列号:
Q9HBH9
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human MKNK2 Protein
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Human MKNK2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


基因位点
Cytogenetic band: 19p13.3 by HGNC 19p13.3 by Entrez Gene 19p13.3 by Ensembl
MKNK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Monomer. Interacts with the C-terminal regions of EIF4G1 and EIF4G2; this interaction is promoted when MAPK pathways are repressed but repressed upon ERK proteins activation. Also binds to dephosphorylated MAPK3/ERK1 and MAPK1/ERK2. Isoform 1 interaction with phosphorylated MAPK3/ERK1 and MAPK1/ERK2 protects it from dephosphorylation and inactivation. Isoform 2 interacts with ESR2 and EIF4E in the nucleus.


功能:
Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal.


亚细胞位置:
Isoform 1 Cytoplasm


该产品尚未在任何出版物中被引用。

[1].
"Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor beta."

[2].
"Regulation of arsenic trioxide-induced cellular responses by Mnk1 and Mnk2."

[3].
"The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells."

[4].
"Essential role for Mnk kinases in type II interferon (IFNgamma) signaling and its suppressive effects on normal hematopoiesis."

[5].
"The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases)."

[6].
"Crystal structures of the Mnk2 kinase domain reveal an inhibitory conformation and a zinc binding site."

[7].
"The DNA sequence and biology of human chromosome 19."

[8].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[9].
"The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization."

[10].
"Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2."
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