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首页  >  重组蛋白  >  Human MAPK14 Recombinant Protein
MAPK14 (基因名), Mitogen-activated protein kinase 14 (蛋白名), MK14_HUMAN.
产品名称:

Human MAPK14/ Mitogen-activated protein kinase 14 Recombinant Protein
促分裂原活化蛋白激酶14

货号:

R9114h

商标:
EIAab®
监管等级:
别名:

Cytokine suppressive anti-inflammatory drug-binding protein, MAP kinase MXI2, MAX-interacting protein 2, Mitogen-activated protein kinase p38 alpha, Stress-activated protein kinase 2a, CSAID-binding protein, MAP kinase p38 alpha, SAPK2a, MAP kinase 14, CSBP, CSBP1, CSBP2, CSPB1, MXI2, SAPK2A

序列号:
Q16539
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Neurosciences
Human MAPK14 Protein
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Human MAPK14 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 6p21.31 by HGNC 6p21.31 by Entrez Gene 6p21.31 by Ensembl
MAPK14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Component of a signaling complex containing at least AKAP13, PKN1, MAPK14, ZAK and MAP2K3. Within this complex, AKAP13 interacts directly with PKN1, which in turn recruits MAPK14, MAP2K3 and ZAK (PubMed:21224381). Binds to a kinase interaction motif within the protein tyrosine phosphatase, PTPRR (By similarity). This interaction retains MAPK14 in the cytoplasm and prevents nuclear accumulation (By similarity). Interacts with SPAG9 and GADD45A (By similarity). Interacts with CDC25B, CDC25C, DUSP1, DUSP10, DUSP16, NP60, SUPT20H and TAB1. Interacts with casein kinase II subunits CSNK2A1 and CSNK2B. Interacts with PPM1D. Interacts with CDK5RAP3; recruits PPM1D to MAPK14 and may regulate its dephosphorylation (PubMed:21283629).


功能:
(Microbial infection) Activated by phosphorylation by M.tuberculosis EsxA in T-cells leading to inhibition of IFN-gamma production; phosphorylation is apparent within 15 minute and is inhibited by kinase-specific inhibitors SB203580 and siRNA (PubMed:21586573).


亚细胞位置:
Cytoplasm Nucleus


该产品尚未在任何出版物中被引用。

[1].
"Prevention of MKK6-dependent activation by binding to p38alpha MAP kinase."

[2].
"MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha."

[3].
"Distinct carboxy-termini confer divergent characteristics to the mitogen-activated protein kinase p38alpha and its splice isoform Mxi2."

[4].
"Stress-induced activation of protein kinase CK2 by direct interaction with p38 mitogen-activated protein kinase."

[5].
"Molecular cloning of human p38 MAP kinase."
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