MAPK12 (基因名), Mitogen-activated protein kinase 12 (蛋白名), MK12_HUMAN.
Human MAPK12/ Mitogen-activated protein kinase 12 Recombinant Protein
Extracellular signal-regulated kinase 6, Mitogen-activated protein kinase p38 gamma, Stress-activated protein kinase 3, ERK-6, MAP kinase p38 gamma, MAP kinase 12, ERK6, SAPK3
>90% by SDS-PAGE
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50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
Store at -20°C. (Avoid repeated freezing and thawing.)
Monomer. Interacts with the PDZ domain of the syntrophin SNTA1. Interacts with SH3BP5. Interacts with LIN7C, SCRIB and SYNJ2BP.
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration.
Cytoplasm Nucleus Mitochondrion Mitochondrial when associated with SH3BP5. In skeletal muscle colocalizes with SNTA1 at the neuromuscular junction and throughout the sarcolemma (By similarity).
MSSPPPARSG | FYRQEVTKTA | WEVRAVYRDL | QPVGSGAYGA | VCSAVDGRTG |
AKVAIKKLYR | PFQSELFAKR | AYRELRLLKH | MRHENVIGLL | DVFTPDETLD |
DFTDFYLVMP | FMGTDLGKLM | KHEKLGEDRI | QFLVYQMLKG | LRYIHAAGII |
HRDLKPGNLA | VNEDCELKIL | DFGLARQADS | EMTGYVVTRW | YRAPEVILNW |
MRYTQTVDIW | SVGCIMAEMI | TGKTLFKGSD | HLDQLKEIMK | VTGTPPAEFV |
QRLQSDEAKN | YMKGLPELEK | KDFASILTNA | SPLAVNLLEK | MLVLDAEQRV |
TAGEALAHPY | FESLHDTEDE | PQVQKYDDSF | DDVDRTLDEW | KRVTYKEVLS |
FKPPRQLGAR | VSKETPL
"Assignment of the human stress-activated protein kinase-3 gene (SAPK3) to chromosome 22q13.3 by fluorescence in situ hybridization."
"Cardiac expression and subcellular localization of the p38 mitogen-activated protein kinase member, stress-activated protein kinase-3 (SAPK3)."
"Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest."
"Stress-activated protein kinase-3 interacts with the PDZ domain of alpha1-syntrophin. A mechanism for specific substrate recognition."
"ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation."
"Loss of p38gamma MAPK induces pleiotropic mitotic defects and massive cell death."
"p38γ mitogen-activated protein kinase contributes to oncogenic properties maintenance and resistance to poly (ADP-ribose)-polymerase-1 inhibition in breast cancer."
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."
"p38gamma regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock."
"p38alpha and p38gamma mediate oncogenic ras-induced senescence through differential mechanisms."
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