MAPK10 (基因名), Mitogen-activated protein kinase 10 (蛋白名), MK10_HUMAN.
Human MAPK10/ Mitogen-activated protein kinase 10 Recombinant Protein
MAP kinase p49 3F12, Stress-activated protein kinase 1b, Stress-activated protein kinase JNK3, c-Jun N-terminal kinase 3, SAPK1b, MAP kinase 10, JNK3, JNK3A, PRKM10, SAPK1B
>90% by SDS-PAGE
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50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
Store at -20°C. (Avoid repeated freezing and thawing.)
Interacts with MAPKBP1 (By similarity). Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and SPAG9/MAPK8IP4/JIP-4. These proteins also bind other components of the JNK signaling pathway. Interacts with HDAC9. Interacts with ARRB2; the interaction enhances MAPK10 activation by MAP3K5. Interacts with SARM1.
Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692).
Cytoplasm Membrane Lipid-anchor Nucleus Mitochondrion Palmitoylation regulates MAPK10 trafficking to cytoskeleton. Recruited to the mitochondria in the presence of SARM1 (By similarity).
MSLHFLYYCS | EPTLDVKIAF | CQGFDKQVDV | SYIAKHYNMS | KSKVDNQFYS |
VEVGDSTFTV | LKRYQNLKPI | GSGAQGIVCA | AYDAVLDRNV | AIKKLSRPFQ |
NQTHAKRAYR | ELVLMKCVNH | KNIISLLNVF | TPQKTLEEFQ | DVYLVMELMD |
ANLCQVIQME | LDHERMSYLL | YQMLCGIKHL | HSAGIIHRDL | KPSNIVVKSD |
CTLKILDFGL | ARTAGTSFMM | TPYVVTRYYR | APEVILGMGY | KENVDIWSVG |
CIMGEMVRHK | ILFPGRDYID | QWNKVIEQLG | TPCPEFMKKL | QPTVRNYVEN |
RPKYAGLTFP | KLFPDSLFPA | DSEHNKLKAS | QARDLLSKML | VIDPAKRISV |
DDALQHPYIN | VWYDPAEVEA | PPPQIYDKQL | DEREHTIEEW | KELIYKEVMN |
SEEKTKNGVV | KGQPSPSGAA | VNSSESLPPS | SSVNDISSMS | TDQTLASDTD |
SSLEASAGPL | GCCR
"Selective interaction of JNK protein kinase isoforms with transcription factors."
"Truncation of the CNS-expressed JNK3 in a patient with a severe developmental epileptic encephalopathy."
"Activation of JNK3 alpha 1 requires both MKK4 and MKK7: kinetic characterization of in vitro phosphorylated JNK3 alpha 1."
"p493F12 kinase: a novel MAP kinase expressed in a subset of neurons in the human nervous system."
"JNK regulates the photic response of the mammalian circadian clock."
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