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MAPK4 (基因名), Mitogen-activated protein kinase 4 (蛋白名), MK04_HUMAN.
产品名称:

Human MAPK4/ Mitogen-activated protein kinase 4 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Extracellular signal-regulated kinase 4, MAP kinase isoform p63, ERK-4, p63-MAPK, MAP kinase 4, ERK4, PRKM4

序列号:
P31152
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human MAPK4 Protein
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Human MAPK4 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


基因位点
Cytogenetic band: 18q21.1-q21.2 by HGNC 18q21.1-q21.2 by Entrez Gene 18q21.1-q21.2 by Ensembl
MAPK4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homodimer. Heterodimer with ERK3/MAPK6. Interacts with (via FRIEDE motif) MAPKAPK5.


功能:
Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle.


亚细胞位置:
Cytoplasm Nucleus Translocates to the cytoplasm following interaction with MAPKAPK5.


该产品尚未在任何出版物中被引用。

[1].
"Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway."

[2].
"Docking of PRAK/MK5 to the atypical MAPKs ERK3 and ERK4 defines a novel MAPK interaction motif."

[3].
"Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5."

[4].
"Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5."

[5].
"Genomic loci of human mitogen-activated protein kinases."

[6].
"Heterogeneous expression of four MAP kinase isoforms in human tissues."

[7].
"Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family."

[8].
"Comparative molecular dynamics simulations of mitogen-activated protein kinase-activated protein kinase 5."

[9].
"The protein interaction landscape of the human CMGC kinase group."

[10].
"Toward a comprehensive characterization of a human cancer cell phosphoproteome."
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