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MITF (基因名), Microphthalmia-associated transcription factor (蛋白名), MITF_HUMAN.
产品名称:

Human MITF/ Microphthalmia-associated transcription factor Recombinant Protein
Microphthalmia-associated转录因子

货号:

R0547h

商标:
EIAab®
监管等级:
别名:

Class E basic helix-loop-helix protein 32, bHLHe32, BHLHE32

序列号:
O75030
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Immunology
Human MITF Protein
规格 & 价格: cart
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Human MITF Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 3p13 by HGNC 3p13 by Entrez Gene 3p13 by Ensembl
MITF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA in the form of homodimer or heterodimer with either TFE3, TFEB or TFEC. Interacts with KARS. Identified in a complex with HINT1 and CTNNB1.


功能:
Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.


亚细胞位置:
Nucleus


该产品尚未在任何出版物中被引用。

[1].
"Frequent mutations in the MITF pathway in melanoma."

[2].
"Sumoylation of MITF and its related family members TFE3 and TFEB."

[3].
"Cloning of MITF, the human homolog of the mouse microphthalmia gene and assignment to chromosome 3p14.1-p12.3."

[4].
"The MITF, p.E318K Variant, as a Risk Factor for Pheochromocytoma and Paraganglioma."

[5].
"Biallelic Mutations in MITF Cause Coloboma, Osteopetrosis, Microphthalmia, Macrocephaly, Albinism, and Deafness."
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