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Misp (基因名), Mitotic interactor and substrate of PLK1 (蛋白名), MISP_MOUSE.
产品名称:

Mouse Misp/ Mitotic interactor and substrate of PLK1 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Mitotic spindle positioning protein

序列号:
Q9D279
来源:
E.coli
种属:
Mouse
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Mouse Misp Protein
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Mouse Misp Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


通用注释


亚单元:
Associates with F-actin. Interacts with DCTN1; this interaction regulates DCTN1 distribution at the cell cortex. Interacts with PTK2/FAK and MAPRE1.


功能:
Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytoskeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus.


亚细胞位置:
Cell junction Focal adhesion Cytoplasm Cytoskeleton Cytoplasm Cell cortex Predominantly localizes to cortical actin structures during interphase and mitosis. Present in retraction fibers, which are formed at former adhesion sites during mitosis, and at spicular membrane protrusions in re-attaching cytokinetic cells. Partially colocalizes with cytoplasmic F-actin. Not detected at microtubules at interphase, nor at spindle during mitosis (By similarity).


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