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MIP (基因名), Lens fiber major intrinsic protein (蛋白名), MIP_HUMAN.
产品名称:

Human MIP/ Lens fiber major intrinsic protein Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Aquaporin-0, MIP26, MP26, AQP0

序列号:
P30301
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human MIP Protein
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Human MIP Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


基因位点
Cytogenetic band: 12q13 by HGNC 12q13 by Entrez Gene 12q13 by Ensembl
MIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homotetramer (PubMed:24120416). Homooctamer formed by head-to-head interaction between homotetramers from adjoining membranes. Interacts with CALM; one CALM molecule interacts with the cytoplasmic domains of two aquaporins, leading to channel closure.


功能:
Water channel (PubMed:24120416). Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). Plays a role in cell-to-cell adhesion and facilitates gap junction coupling (PubMed:24120416).


亚细胞位置:
Cell membrane Multi-pass membrane protein Cell junction Gap junction


该产品尚未在任何出版物中被引用。

[1].
"Genomic cloning, complete nucleotide sequence, and structure of the human gene encoding the major intrinsic protein (MIP) of the lens."

[2].
"A novel mutation in major intrinsic protein of the lens gene (MIP) underlies autosomal dominant cataract in a Chinese family."

[3].
"Missense mutations in MIP underlie autosomal dominant 'polymorphic' and lamellar cataracts linked to 12q."

[4].
"The lipidation profile of aquaporin-0 correlates with the acyl composition of phosphoethanolamine lipids in lens membranes."

[5].
"Identification and Functional Analysis of a Novel MIP Gene Mutation Associated with Congenital Cataract in a Chinese Family."

[6].
"An MIP/AQP0 mutation with impaired trafficking and function underlies an autosomal dominant congenital lamellar cataract."

[7].
"Functional characterization of an AQP0 missense mutation, R33C, that causes dominant congenital lens cataract, reveals impaired cell-to-cell adhesion."

[8].
"A novel mutation in MIP associated with congenital nuclear cataract in a Chinese family."

[9].
"A novel mutation in the major intrinsic protein (MIP) associated with autosomal dominant congenital cataracts in a Chinese family."

[10].
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."
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