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SPEN (基因名), Msx2-interacting protein (蛋白名), MINT_HUMAN.
产品名称:

Human SPEN/ Msx2-interacting protein Recombinant Protein
Msx2-interacting蛋白质

货号:

R15514h

商标:
EIAab®
监管等级:
别名:

SMART/HDAC1-associated repressor protein, SPEN homolog, KIAA0929, MINT, SHARP

序列号:
Q96T58
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human SPEN Protein
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Human SPEN Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 1p36.21-p36.13 by HGNC 1p36.21-p36.13 by Entrez Gene 1p36.21-p36.13 by Ensembl
SPEN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with MSX2 and HIPK3 (By similarity). Interacts with NCOR2, HDAC1, HDAC2, RBBP4, MBD3 and MTA1L1. Interacts with RBPSUH; this interaction may prevent the interaction between RBPSUH and NOTCH1. Interacts with the nuclear receptors RAR and PPARD. Interacts with RAR in absence of ligand. Binds to the steroid receptor RNA coactivator SRA. Interacts with Epstein-Barr virus BSFL2/BMLF1.


功能:
May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA.


亚细胞位置:
Nucleus Associates with chromatin.


该产品尚未在任何出版物中被引用。

[1].
"Sharp, an inducible cofactor that integrates nuclear receptor repression and activation."

[2].
"Interaction of the Epstein-Barr virus mRNA export factor EB2 with human Spen proteins SHARP, OTT1, and a novel member of the family, OTT3, links Spen proteins with splicing regulation and mRNA export."

[3].
"A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling."

[4].
"The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling."

[5].
"Drosophila split ends homologue SHARP functions as a positive regulator of Wnt/beta-catenin/T-cell factor signaling in neoplastic transformation."
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