首页 > 重组蛋白 > Human MICALL2 Recombinant Protein

MICALL2 (基因名), MICAL-like protein 2 (蛋白名), MILK2_HUMAN.

产品名称:

Human MICALL2/ MICAL-like protein 2 Recombinant Protein

货号:

商标:

EIAab^®

监管等级:

RUO

别名:

Junctional Rab13-binding protein, Molecule interacting with CasL-like 2, MICAL-L2, JRAB

序列号:

Q8IY33

来源:

E.coli

种属:

Human

标签:

His

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

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Human MICALL2 Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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基因位点

Cytogenetic band: 7p22.3 by HGNC 7p22.3 by Entrez Gene 7p22.3 by Ensembl

MICALL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Interacts with RAB13 (GTP-bound form); competes with RAB8A and is involved in tight junctions assembly. Interacts with RAB8A; competes with RAB13 and is involved in E-cadherin endocytic recycling (By similarity). Interacts with RAB8B (By similarity). Interacts (preferentially in opened conformation) with ACTN1 and ACTN4; stimulated by RAB13 activation (By similarity). Interacts (via CH domain) with the filamins FLNA, FLNB and FLNC (via actin-binding domain).

功能:

Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth.

亚细胞位置:

Cell membrane Peripheral membrane protein Cell junction Tight junction Recycling endosome Cell projection Cytoplasm Cytoskeleton Cytoplasm Cytosol

数据库链接

UniGene:

Hs.376617

SMR:

Q8IY33

STRING:

9606.ENSP00000297508

KEGG:

hsa:79778

Pfam:

PF00307

Uniprot:

Q8IY33

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序列长度:

904

序列:

仅供参考，详细请咨询（services@eiaab.com）

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3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"JRAB/MICAL-L2 is a junctional Rab13-binding protein mediating the endocytic recycling of occludin."

(PMID: 16525024)

[2].

"MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion."

(PMID: 12110185)

[3].

"Junctional Rab13-binding protein (JRAB) regulates cell spreading via filamins."

(PMID: 23890175)

[4].

"Complete sequencing and characterization of 21,243 full-length human cDNAs."

(PMID: 14702039)

[5].

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

(PMID: 15489334)

[6].

"Architecture of the human interactome defines protein communities and disease networks."

(PMID: 28514442)

[7].

"A human interactome in three quantitative dimensions organized by stoichiometries and abundances."

(PMID: 26496610)

[8].

"Silencing of MICAL-L2 suppresses malignancy of ovarian cancer by inducing mesenchymal-epithelial transition."

(PMID: 25864591)

[9].

"A proteome-scale map of the human interactome network."

(PMID: 25416956)

[10].

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."

(PMID: 24275569)

[1].

人MICALL2重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人MICALL2重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人MICALL2重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人MICALL2重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人MICALL2重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人MICALL2重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人MICALL2重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人MICALL2重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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