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MICALL2 (基因名), MICAL-like protein 2 (蛋白名), MILK2_HUMAN.
产品名称:

Human MICALL2/ MICAL-like protein 2 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Junctional Rab13-binding protein, Molecule interacting with CasL-like 2, MICAL-L2, JRAB

序列号:
Q8IY33
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human MICALL2 Protein
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Human MICALL2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


基因位点
Cytogenetic band: 7p22.3 by HGNC 7p22.3 by Entrez Gene 7p22.3 by Ensembl
MICALL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with RAB13 (GTP-bound form); competes with RAB8A and is involved in tight junctions assembly. Interacts with RAB8A; competes with RAB13 and is involved in E-cadherin endocytic recycling (By similarity). Interacts with RAB8B (By similarity). Interacts (preferentially in opened conformation) with ACTN1 and ACTN4; stimulated by RAB13 activation (By similarity). Interacts (via CH domain) with the filamins FLNA, FLNB and FLNC (via actin-binding domain).


功能:
Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth.


亚细胞位置:
Cell membrane Peripheral membrane protein Cell junction Tight junction Recycling endosome Cell projection Cytoplasm Cytoskeleton Cytoplasm Cytosol


该产品尚未在任何出版物中被引用。

[1].
"JRAB/MICAL-L2 is a junctional Rab13-binding protein mediating the endocytic recycling of occludin."

[2].
"MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion."

[3].
"Junctional Rab13-binding protein (JRAB) regulates cell spreading via filamins."

[4].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."

[5].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[6].
"Architecture of the human interactome defines protein communities and disease networks."

[7].
"A human interactome in three quantitative dimensions organized by stoichiometries and abundances."

[8].
"Silencing of MICAL-L2 suppresses malignancy of ovarian cancer by inducing mesenchymal-epithelial transition."

[9].
"A proteome-scale map of the human interactome network."

[10].
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
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