MICALL2 (基因名), MICAL-like protein 2 (蛋白名), MILK2_HUMAN.
Human MICALL2/ MICAL-like protein 2 Recombinant Protein
Junctional Rab13-binding protein, Molecule interacting with CasL-like 2, MICAL-L2, JRAB
>90% by SDS-PAGE
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50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
Store at -20°C. (Avoid repeated freezing and thawing.)
Interacts with RAB13 (GTP-bound form); competes with RAB8A and is involved in tight junctions assembly. Interacts with RAB8A; competes with RAB13 and is involved in E-cadherin endocytic recycling (By similarity). Interacts with RAB8B (By similarity). Interacts (preferentially in opened conformation) with ACTN1 and ACTN4; stimulated by RAB13 activation (By similarity). Interacts (via CH domain) with the filamins FLNA, FLNB and FLNC (via actin-binding domain).
Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth.
Cell membrane Peripheral membrane protein Cell junction Tight junction Recycling endosome Cell projection Cytoplasm Cytoskeleton Cytoplasm Cytosol
MAAIRALQQW | CRQQCEGYRD | VNICNMTTSF | RDGLAFCAIL | HRHRPDLINF |
SALKKENIYE | NNKLAFRVAE | EHLGIPALLD | AEDMVALKVP | DRLSILTYVS |
QYYNYFHGRS | PIGGMAGVKR | ASEDSEEEPS | GKKAPVQAAK | LPSPAPARKP |
PLSPAQTNPV | VQRRNEGAGG | PPPKTDQALA | GSLVSSTCGV | CGKHVHLVQR |
HLADGRLYHR | SCFRCKQCSC | TLHSGAYKAT | GEPGTFVCTS | HLPAAASASP |
KLTGLVPRQP | GAMGVDSRTS | CSPQKAQEAN | KARPSAWEPA | AGNSPARASV |
PAAPNPAATS | ATSVHVRSPA | RPSESRLAPT | PTEGKVRPRV | TNSSPMGWSS |
AAPCTAAAAS | HPAVPPSAPD | PRPATPQGGG | APRVAAPQTT | LSSSSTSAAT |
VDPPAWTPSA | SRTQQARNKF | FQTSAVPPGT | SLSGRGPTPS | LVLSKDSSKE |
QARNFLKQAL | SALEEAGAPA | PGRPSPATAA | VPSSQPKTEA | PQASPLAKPL |
QSSSPRVLGL | PSRMEPPAPL | STSSTSQASA | LPPAGRRNLA | ESSGVGRVGA |
GSRPKPEAPM | AKGKSTTLTQ | DMSTSLQEGQ | EDGPAGWRAN | LKPVDRRSPA |
ERTLKPKEPR | ALAEPRAGEA | PRKVSGSFAG | SVHITLTPVR | PDRTPRPASP |
GPSLPARSPS | PPRRRRLAVP | ASLDVCDNWL | RPEPPGQEAR | VQSWKEEEKK |
PHLQGKPGRP | LSPANVPALP | GETVTSPVRL | HPDYLSPEEI | QRQLQDIERR |
LDALELRGVE | LEKRLRAAEG | DDAEDSLMVD | WFWLIHEKQL | LLRQESELMY |
KSKAQRLEEQ | QLDIEGELRR | LMAKPEALKS | LQERRREQEL | LEQYVSTVND |
RSDIVDSLDE | DRLREQEEDQ | MLRDMIEKLG | LQRKKSKFRL | SKIWSPKSKS |
"JRAB/MICAL-L2 is a junctional Rab13-binding protein mediating the endocytic recycling of occludin."
"MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion."
"Junctional Rab13-binding protein (JRAB) regulates cell spreading via filamins."
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"Architecture of the human interactome defines protein communities and disease networks."
"A human interactome in three quantitative dimensions organized by stoichiometries and abundances."
"Silencing of MICAL-L2 suppresses malignancy of ovarian cancer by inducing mesenchymal-epithelial transition."
"A proteome-scale map of the human interactome network."
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
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