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MIF (基因名), Macrophage migration inhibitory factor (蛋白名), MIF_HUMAN.
产品名称:

Human MIF/ Macrophage migration inhibitory factor Recombinant Protein
巨噬细胞迁移抑制因子

货号:

R0698h

商标:
EIAab®
监管等级:
别名:

Glycosylation-inhibiting factor, L-dopachrome isomerase, L-dopachrome tautomerase, Phenylpyruvate tautomerase, GIF, MIF, GLIF, MMIF

序列号:
P14174
来源:
E.coli
种属:
Human
标签:
His
序列:
1-115aa
预估分子量:
12.65 kDa (monomer)
纯度:
Greater than 95% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Immunology
  • Human MIF Protein
  • Human MIF Protein
  • Human MIF Protein
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Human MIF Protein
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产品说明书
数据表: 下载说明书
MSDS: MSDS


R&D 技术数据
The sequence analysis of human MIF protein including hydrophilcity, hydrophobicity and antigenicity.
Human MIF Protein
Recombinant human MIF protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 22q11.23 by HGNC 22q11.23 by Entrez Gene 22q11.23 by Ensembl
MIF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homotrimer. Interacts with CXCR2 extracellular domain (By similarity). Interacts with the CD74 extracellular domain, COPS5 and BNIPL.


功能:
Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.


亚细胞位置:
Secreted Cytoplasm Does not have a cleavable signal sequence and is secreted via a specialized, non-classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens.



[1].
"Serum macrophage migration inhibitory factor (MIF) in the intercritical phase of hereditary periodic fevers and its relationship with the MIF-173G/C polymorphism."

[2].
"A polymorphism in the macrophage migration inhibitory factor gene is involved in the genetic predisposition of Crohn's disease and associated with cumulative steroid doses."

[3].
"A macrophage migration inhibitory factor promoter polymorphism is associated with high-density parasitemia in children with malaria."

[4].
"Correlation of rheumatoid arthritis severity with the genetic functional variants and circulating levels of macrophage migration inhibitory factor."

[5].
"Coumarin and chromen-4-one analogues as tautomerase inhibitors of macrophage migration inhibitory factor: discovery and X-ray crystallography."

[6].
"A novel 5'-flanking region polymorphism of macrophage migration inhibitory factor is associated with systemic-onset juvenile idiopathic arthritis."

[7].
"Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1."

[8].
"Pro-1 of macrophage migration inhibitory factor functions as a catalytic base in the phenylpyruvate tautomerase activity."

[9].
"Molecular cloning and functional expression of a cDNA encoding glycosylation-inhibiting factor."

[10].
"Molecular cloning of a cDNA encoding a human macrophage migration inhibitory factor."
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