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MIF (基因名), Macrophage migration inhibitory factor (蛋白名), MIF_BOVIN.
产品名称:

Bovine MIF/ Macrophage migration inhibitory factor Recombinant Protein
巨噬细胞迁移抑制因子

货号:

R0698b

商标:
EIAab®
监管等级:
别名:

L-dopachrome isomerase, L-dopachrome tautomerase, Phenylpyruvate tautomerase, p12A, MIF

序列号:
P80177
来源:
E.coli
种属:
Bovine
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Immunology
Bovine MIF Protein
规格 & 价格: cart
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Bovine MIF Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
通用注释


亚单元:
Homotrimer. Interacts with BNIPL (By similarity). Interacts with the CD74 extracellular domain. Interacts with COPS5 and with the CXCR2 extracellular domain.


功能:
Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.


亚细胞位置:
Secreted Cytoplasm Does not have a cleavable signal sequence and is secreted via a specialized, non-classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens (By similarity).



[1].
Biji Mathew, Jeffrey R Jacobson, Jessica H Siegler, Jaideep Moitra, Micheal Blasco, Lishi Xie, Crystal Unzueta, Tong Zhou, Carrie Evenoski...
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