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Spata18 (基因名), Mitochondria-eating protein (蛋白名), MIEAP_RAT.
产品名称:

Rat Spata18/ Mitochondria-eating protein Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Spermatid-expressing gene 1 protein, Spermatogenesis-associated protein 18, Spetex-1, Mieap, Spetex1

序列号:
Q6AYL6
来源:
E.coli
种属:
Rat
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Rat Spata18 Protein
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Rat Spata18 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Interacts (via coiled-coil domains) with BNIP3L (via BH3 domain). Interacts (via coiled-coil domains) with BNIP3 (via BH3 domain). Colocalizes with BNIP3 and BNIP3L at the mitochondrion outer membrane.


功能:
Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes (By similarity). The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). May have a role in spermatogenesis, especially in cell differentiation from late elongate spermatids to mature spermatozoa.


亚细胞位置:
Cytoplasm Mitochondrion outer membrane Localizes to the cytoplasm under normal conditions. Relocalizes to mitochondrion outer membrane following cellular stress.


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