首页 > 重组蛋白 > Human SPATA18 Recombinant Protein

SPATA18 (基因名), Mitochondria-eating protein (蛋白名), MIEAP_HUMAN.

产品名称:

Human SPATA18/ Mitochondria-eating protein Recombinant Protein

货号:

商标:

EIAab^®

监管等级:

RUO

别名:

Spermatogenesis-associated protein 18, MIEAP

序列号:

Q8TC71

来源:

E.coli

种属:

Human

标签:

His

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

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Human SPATA18 Protein

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产品说明书

说明书:

MSDS:

数据
文献
出版物
序列 / 3D
常见问题解答
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基因位点

Cytogenetic band: 4q12 by HGNC 4q12 by Entrez Gene 4q12 by Ensembl

SPATA18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Interacts (via coiled-coil domains) with BNIP3L (via BH3 domain). Interacts (via coiled-coil domains) with BNIP3 (via BH3 domain).

功能:

Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix.

亚细胞位置:

Cytoplasm Mitochondrion outer membrane Localizes to the cytoplasm under normal conditions (PubMed:21264228). Relocalizes to mitochondrion outer membrane following cellular stress. Colocalizes with BNIP3 and BNIP3L at the mitochondrion outer membrane (PubMed:22292033).

数据库链接

UniGene:

Hs.527090

SMR:

Q8TC71

STRING:

9606.ENSP00000295213

KEGG:

hsa:132671

MIM:

612814

Pfam:

PF16026

Uniprot:

Q8TC71

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序列长度:

538

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

538:

SRCRSRSLSP | ICPRSQIGLN | TMSRSRSPSP | IRCGLPRF

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"SPATA18, a spermatogenesis-associated gene, is a novel transcriptional target of p53 and p63."

(PMID: 21300779)

[2].

"BNIP3 and NIX mediate Mieap-induced accumulation of lysosomal proteins within mitochondria."

(PMID: 22292033)

[3].

"Mieap, a p53-inducible protein, controls mitochondrial quality by repairing or eliminating unhealthy mitochondria."

(PMID: 21264228)

[4].

"Possible existence of lysosome-like organella within mitochondria and its role in mitochondrial quality control."

(PMID: 21264221)

[5].

"Complete sequencing and characterization of 21,243 full-length human cDNAs."

(PMID: 14702039)

[6].

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

(PMID: 15489334)

[7].

"Possible role of p53/Mieap-regulated mitochondrial quality control as a tumor suppressor in human breast cancer."

(PMID: 30290054)

[8].

"A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface."

(PMID: 26638075)

[9].

"Charting the landscape of tandem BRCT domain-mediated protein interactions."

(PMID: 22990118)

[10].

"Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."

(PMID: 21873635)

[1].

人SPATA18重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人SPATA18重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人SPATA18重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人SPATA18重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人SPATA18重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人SPATA18重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人SPATA18重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人SPATA18重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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