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SPATA18 (基因名), Mitochondria-eating protein (蛋白名), MIEAP_HUMAN.
产品名称:

Human SPATA18/ Mitochondria-eating protein Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Spermatogenesis-associated protein 18, MIEAP

序列号:
Q8TC71
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human SPATA18 Protein
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Human SPATA18 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


基因位点
Cytogenetic band: 4q12 by HGNC 4q12 by Entrez Gene 4q12 by Ensembl
SPATA18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts (via coiled-coil domains) with BNIP3L (via BH3 domain). Interacts (via coiled-coil domains) with BNIP3 (via BH3 domain).


功能:
Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix.


亚细胞位置:
Cytoplasm Mitochondrion outer membrane Localizes to the cytoplasm under normal conditions (PubMed:21264228). Relocalizes to mitochondrion outer membrane following cellular stress. Colocalizes with BNIP3 and BNIP3L at the mitochondrion outer membrane (PubMed:22292033).


该产品尚未在任何出版物中被引用。

[1].
"SPATA18, a spermatogenesis-associated gene, is a novel transcriptional target of p53 and p63."

[2].
"BNIP3 and NIX mediate Mieap-induced accumulation of lysosomal proteins within mitochondria."

[3].
"Mieap, a p53-inducible protein, controls mitochondrial quality by repairing or eliminating unhealthy mitochondria."

[4].
"Possible existence of lysosome-like organella within mitochondria and its role in mitochondrial quality control."

[5].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."

[6].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[7].
"Possible role of p53/Mieap-regulated mitochondrial quality control as a tumor suppressor in human breast cancer."

[8].
"A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface."

[9].
"Charting the landscape of tandem BRCT domain-mediated protein interactions."

[10].
"Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
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