MICA (基因名), MHC class I polypeptide-related sequence A (蛋白名), MICA_HUMAN.
Human MICA/ MHC class I polypeptide-related sequence A Recombinant Protein
>90% by SDS-PAGE
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50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
Store at -20°C. (Avoid repeated freezing and thawing.)
Unlike classical MHC class I molecules, does not form a heterodimer with beta-2-microglobulin. Binds as a monomer to a KLRK1/NKG2D homodimer. KLRK1 forms a complex with HCST/DAP10 in which KLRK1 binds MICA while HCST acts as an adapter molecule which enables signal transduction. Interacts with PDIA6 on the surface of tumor cells, leading to disulfide bond reduction which is required for release of MICA from tumor cells. Interacts with human cytomegalovirus/HHV-5 protein UL142.
Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Cell membrane Single-pass type I membrane protein Cytoplasm Expressed on the cell surface in gastric epithelium, endothelial cells and fibroblasts and in the cytoplasm in keratinocytes and monocytes. Infection with human adenovirus 5 suppresses cell surface expression due to the adenoviral E3-19K protein which causes retention in the endoplasmic reticulum.
MGLGPVFLLL | AGIFPFAPPG | AAAEPHSLRY | NLTVLSWDGS | VQSGFLTEVH |
LDGQPFLRCD | RQKCRAKPQG | QWAEDVLGNK | TWDRETRDLT | GNGKDLRMTL |
AHIKDQKEGL | HSLQEIRVCE | IHEDNSTRSS | QHFYYDGELF | LSQNLETKEW |
TMPQSSRAQT | LAMNVRNFLK | EDAMKTKTHY | HAMHADCLQE | LRRYLKSGVV |
LRRTVPPMVN | VTRSEASEGN | ITVTCRASGF | YPWNITLSWR | QDGVSLSHDT |
QQWGDVLPDG | NGTYQTWVAT | RICQGEEQRF | TCYMEHSGNH | STHPVPSGKV |
LVLQSHWQTF | HVSAVAAAAI | FVIIIFYVRC | CKKKTSAAEG | PELVSLQVLD |
QHPVGTSDHR | DATQLGFQPL | MSDLGSTGST | EGA
"Diagnostic Outcomes of Soluble Major Histocompatibility Complex Class I Related Chain Molecule A and Des-γ Carboxy Prothrombin versus Alpha..."
El-Sherif A A S, Eldin A M K, Higazi A, et al.
From: Immunome Research
"The MICA-A9 triplet repeat polymorphism in the transmembrane region confers additional susceptibility to the development of psoriatic arthritis and is independent of the association of Cw*0602 in psoriasis."
"A second lineage of mammalian major histocompatibility complex class I genes."
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."
"Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection."
"[Association of MICA gene polymorphism and serum soluble MICA level with colorectal cancer]."
"Association analysis of MICA gene polymorphism and MICA-129 dimorphism with inflammatory bowel disease susceptibility in a Spanish population."
"MICA polymorphisms and haplotypes with HLA-B and HLA-DRB1 in Koreans."
"MICA polymorphism in a northern Chinese Han population: The identification of a new MICA allele, MICA*059."
"An influence of HLA-A, B, DR, DQ, and MICA on the occurrence of Celiac disease in patients with type 1 diabetes."
"The major genetic determinants of HIV-1 control affect HLA class I peptide presentation."
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