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MICAL2 (基因名), [F-actin]-monooxygenase MICAL2 (蛋白名), MICA2_HUMAN.
产品名称:

Human MICAL2/ [F-actin]-monooxygenase MICAL2 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Molecule interacting with CasL protein 2, MICAL-2, KIAA0750, MICAL2PV1, MICAL2PV2

序列号:
O94851
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human MICAL2 Protein
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Human MICAL2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


基因位点
Cytogenetic band: 11p15.3 by HGNC 11p15.3 by Entrez Gene 11p15.3 by Ensembl
MICAL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with PLXNA4 (By similarity). Interacts with RAB1B (PubMed:15694364).


功能:
Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (PubMed:24440334). In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (By similarity). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA (PubMed:24440334).


亚细胞位置:
Nucleus


该产品尚未在任何出版物中被引用。

[1].
"MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion."

[2].
"Redox modification of nuclear actin by MICAL-2 regulates SRF signaling."

[3].
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."

[4].
"Expression of novel molecules, MICAL2-PV (MICAL2 prostate cancer variants), increases with high Gleason score and prostate cancer progression."

[5].
"The MICAL proteins and rab1: a possible link to the cytoskeleton?"
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