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APOOL (基因名), MICOS complex subunit MIC27 (蛋白名), MIC27_HUMAN.
产品名称:

Human APOOL/ MICOS complex subunit MIC27 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Apolipoprotein O-like, Protein FAM121A, UNQ8193/PRO23204, CXorf33, FAM121A, MIC27

序列号:
Q6UXV4
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human APOOL Protein
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Human APOOL Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


基因位点
Cytogenetic band: Xq21.1 by HGNC Xq21.1 by Entrez Gene Xq21.1 by Ensembl
APOOL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex (PubMed:25764979, PubMed:25781180, PubMed:23704930, PubMed:25764979, PubMed:25781180, PubMed:25997101). The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1, MTX2 and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. Interacts with MINOS1/MIC10, IMMT/MIC60 and APOO/MIC23/MIC26 (PubMed:25764979, PubMed:25781180, PubMed:23704930, PubMed:25764979, PubMed:25781180, PubMed:25997101).


功能:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function (PubMed:23704930), (PubMed:25764979).


亚细胞位置:
Mitochondrion inner membrane Multi-pass membrane protein Mitochondrion


该产品尚未在任何出版物中被引用。

[1].
"APOOL is a cardiolipin-binding constituent of the Mitofilin/MINOS protein complex determining cristae morphology in mammalian mitochondria."

[2].
"The non-glycosylated isoform of MIC26 is a constituent of the mammalian MICOS complex and promotes formation of crista junctions."

[3].
"Detailed analysis of the human mitochondrial contact site complex indicate a hierarchy of subunits."

[4].
"QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology."

[5].
"The DNA sequence of the human X chromosome."

[6].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[7].
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."

[8].
"Mapping the Genetic Landscape of Human Cells."

[9].
"Architecture of the human interactome defines protein communities and disease networks."

[10].
"Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways."
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