APOO (基因名), MICOS complex subunit MIC26 (蛋白名), MIC26_HUMAN.
Human APOO/ MICOS complex subunit MIC26 Recombinant Protein
Apolipoprotein O, MICOS complex subunit MIC23, Protein FAM121B, My025, UNQ1866/PRO4302, FAM121B, MIC23, MIC26
>90% by SDS-PAGE
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50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
Store at -20°C. (Avoid repeated freezing and thawing.)
Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1, MTX2 and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9 (PubMed:25764979, PubMed:25781180, PubMed:25997101). Interacts with IMMT/MIC60 (PubMed:25764979, PubMed:25781180). Interacts with MINOS1/MIC10 and APOOL/MIC27 (PubMed:25764979).
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function (PubMed:25764979). Can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts (PubMed:24743151). Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL (PubMed:16956892).
Mitochondrion inner membrane Single-pass membrane protein Secreted Mitochondrion Golgi apparatus membrane Endoplasmic reticulum membrane Exists in three distinct forms: a glycosylated and secreted form, an ER/Golgi-resident form and a non-glycosylated mitochondrial form.
MFKVIQRSVG | PASLSLLTFK | VYAAPKKDSP | PKNSVKVDEL | SLYSVPEGQS |
KYVEEARSQL | EESISQLRHY | CEPYTTWCQE | TYSQTKPKMQ | SLVQWGLDSY |
DYLQNAPPGF | FPRLGVIGFA | GLIGLLLARG | SKIKKLVYPP | GFMGLAASLY |
YPQQAIVFAQ | VSGERLYDWG | LRGYIVIEDL | WKENFQKPGN | VKNSPGTK
"The non-glycosylated isoform of MIC26 is a constituent of the mammalian MICOS complex and promotes formation of crista junctions."
"Detailed analysis of the human mitochondrial contact site complex indicate a hierarchy of subunits."
"ApoO, a novel apolipoprotein, is an original glycoprotein up-regulated by diabetes in human heart."
"QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology."
"Apolipoprotein O is mitochondrial and promotes lipotoxicity in heart."
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."
"Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
"Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function."
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