首页 > 重组蛋白 > Human APOO Recombinant Protein

APOO (基因名), MICOS complex subunit MIC26 (蛋白名), MIC26_HUMAN.

产品名称:

Human APOO/ MICOS complex subunit MIC26 Recombinant Protein
MICOS复合体亚基

货号:

R10480h

商标:

EIAab^®

监管等级:

RUO

别名:

Apolipoprotein O, MICOS complex subunit MIC23, Protein FAM121B, My025, UNQ1866/PRO4302, FAM121B, MIC23, MIC26

序列号:

Q9BUR5

来源:

E.coli

种属:

Human

标签:

His

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

规格 & 价格:

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Human APOO Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: Xp22.11 by HGNC Xp22.11 by Entrez Gene Xp22.11 by Ensembl

APOO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1, MTX2 and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9 (PubMed:25764979, PubMed:25781180, PubMed:25997101). Interacts with IMMT/MIC60 (PubMed:25764979, PubMed:25781180). Interacts with MINOS1/MIC10 and APOOL/MIC27 (PubMed:25764979).

功能:

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function (PubMed:25764979). Can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts (PubMed:24743151). Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL (PubMed:16956892).

亚细胞位置:

Mitochondrion inner membrane Single-pass membrane protein Secreted Mitochondrion Golgi apparatus membrane Endoplasmic reticulum membrane Exists in three distinct forms: a glycosylated and secreted form, an ER/Golgi-resident form and a non-glycosylated mitochondrial form.

数据库链接

UniGene:

Hs.495851

STRING:

9606.ENSP00000368528

KEGG:

hsa:79135

MIM:

300753

Pfam:

PF09769

Uniprot:

Q9BUR5

相关产品

Mouse Apoo ELISA Kit

Bovine APOO ELISA Kit

Mouse Apoo CLIA Kit

Bovine APOO CLIA Kit

Mouse Apoo Protein

序列长度:

198

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

150:

198:

YPQQAIVFAQ | VSGERLYDWG | LRGYIVIEDL | WKENFQKPGN | VKNSPGTK

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"The non-glycosylated isoform of MIC26 is a constituent of the mammalian MICOS complex and promotes formation of crista junctions."

(PMID: 25764979)

[2].

"Detailed analysis of the human mitochondrial contact site complex indicate a hierarchy of subunits."

(PMID: 25781180)

[3].

"ApoO, a novel apolipoprotein, is an original glycoprotein up-regulated by diabetes in human heart."

(PMID: 16956892)

[4].

"QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology."

(PMID: 25997101)

[5].

"Apolipoprotein O is mitochondrial and promotes lipotoxicity in heart."

(PMID: 24743151)

[6].

"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

(PMID: 20628086)

[7].

"Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease."

(PMID: 19204726)

[8].

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

(PMID: 15489334)

[9].

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."

(PMID: 12975309)

[10].

"Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function."

(PMID: 27499296)

[1].

人MICOS复合体亚基(APOO)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人MICOS复合体亚基(APOO)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人MICOS复合体亚基(APOO)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人MICOS复合体亚基(APOO)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人MICOS复合体亚基(APOO)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人MICOS复合体亚基(APOO)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人MICOS复合体亚基(APOO)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人MICOS复合体亚基(APOO)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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