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MIB1 (基因名), E3 ubiquitin-protein ligase MIB1 (蛋白名), MIB1_HUMAN.
产品名称:

Human MIB1/ E3 ubiquitin-protein ligase MIB1 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

DAPK-interacting protein 1, Mind bomb homolog 1, RING-type E3 ubiquitin transferase MIB1, Zinc finger ZZ type with ankyrin repeat domain protein 2, DIP-1, DIP1, KIAA1323, ZZANK2

序列号:
Q86YT6
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Development Biology
Human MIB1 Protein
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Human MIB1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


基因位点
Cytogenetic band: 18q11.2 by HGNC 18q11.2 by Entrez Gene 18q11.2 by Ensembl
MIB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with CEP131 and PCM1.


功能:
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.


亚细胞位置:
Cytoplasm Cytoplasm Cytoskeleton Microtubule organizing center Centrosome Centriolar satellite Cell membrane Localizes to the plasma membrane (By similarity). According to PubMed:15048887, it is mitochondrial, however such localization remains unclear. Displaced from centriolar satellites in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock.


该产品尚未在任何出版物中被引用。

[1].
"A new cellular stress response that triggers centriolar satellite reorganization and ciliogenesis."

[2].
"Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy."

[3].
"Mapping a dynamic innate immunity protein interaction network regulating type I interferon production."

[4].
"Mind bomb 1 regulation of cFLIP interactions."

[5].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."

[6].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[7].
"Death-associated protein kinase expression in human temporal lobe epilepsy."

[8].
"Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta."

[9].
"A death-associated protein kinase (DAPK)-interacting protein, DIP-1, is an E3 ubiquitin ligase that promotes tumor necrosis factor-induced apoptosis and regulates the cellular levels of DAPK."

[10].
"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
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