首页 > 重组蛋白 > Human MIB1 Recombinant Protein

MIB1 (基因名), E3 ubiquitin-protein ligase MIB1 (蛋白名), MIB1_HUMAN.

产品名称:

Human MIB1/ E3 ubiquitin-protein ligase MIB1 Recombinant Protein

货号:

商标:

EIAab^®

监管等级:

RUO

别名:

DAPK-interacting protein 1, Mind bomb homolog 1, RING-type E3 ubiquitin transferase MIB1, Zinc finger ZZ type with ankyrin repeat domain protein 2, DIP-1, DIP1, KIAA1323, ZZANK2

序列号:

Q86YT6

来源:

E.coli

种属:

Human

标签:

His

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Development Biology

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Human MIB1 Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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基因位点

Cytogenetic band: 18q11.2 by HGNC 18q11.2 by Entrez Gene 18q11.2 by Ensembl

MIB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Interacts with CEP131 and PCM1.

功能:

E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.

亚细胞位置:

Cytoplasm Cytoplasm Cytoskeleton Microtubule organizing center Centrosome Centriolar satellite Cell membrane Localizes to the plasma membrane (By similarity). According to PubMed:15048887, it is mitochondrial, however such localization remains unclear. Displaced from centriolar satellites in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock.

数据库链接

UniGene:

Hs.140903

SMR:

Q86YT6

STRING:

9606.ENSP00000261537

KEGG:

hsa:57534

MIM:

608677

Pfam:

PF12796

Uniprot:

Q86YT6

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序列长度:

1006

序列:

仅供参考，详细请咨询（services@eiaab.com）

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RRILLY

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"A new cellular stress response that triggers centriolar satellite reorganization and ciliogenesis."

(PMID: 24121310)

[2].

"Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy."

(PMID: 23314057)

[3].

"Mapping a dynamic innate immunity protein interaction network regulating type I interferon production."

(PMID: 21903422)

[4].

"Mind bomb 1 regulation of cFLIP interactions."

(PMID: 19710364)

[5].

"Complete sequencing and characterization of 21,243 full-length human cDNAs."

(PMID: 14702039)

[6].

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

(PMID: 15489334)

[7].

"Death-associated protein kinase expression in human temporal lobe epilepsy."

(PMID: 15048887)

[8].

"Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta."

(PMID: 12530964)

[9].

"A death-associated protein kinase (DAPK)-interacting protein, DIP-1, is an E3 ubiquitin ligase that promotes tumor necrosis factor-induced apoptosis and regulates the cellular levels of DAPK."

(PMID: 12351649)

[10].

"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."

(PMID: 10718198)

[1].

人MIB1重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人MIB1重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人MIB1重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人MIB1重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人MIB1重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人MIB1重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人MIB1重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人MIB1重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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