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Mgrn1 (基因名), E3 ubiquitin-protein ligase MGRN1 (蛋白名), MGRN1_RAT.
产品名称:

Rat Mgrn1/ E3 ubiquitin-protein ligase MGRN1 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Mahogunin RING finger protein 1, RING-type E3 ubiquitin transferase MGRN1

序列号:
Q5XIQ4
来源:
E.coli
种属:
Rat
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Rat Mgrn1 Protein
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Rat Mgrn1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


通用注释


亚单元:
Interacts with MC1R and MC4R. Interacts with TSG101. Interacts with mislocalized cytosolically exposed PRNP; this interaction alters MGRN1 subcellular location and causes lysosomal enlargement.


功能:
E3 ubiquitin-protein ligase. Mediates TSG101 monoubiquitination at multiple sites. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination.


亚细胞位置:
Cytoplasm Cytosol Cell membrane Early endosome The endosomal localization is dependent on the interaction with TSG101.


该产品尚未在任何出版物中被引用。
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