EIAab
首页  >  重组蛋白  >  Human MAGOH Recombinant Protein
MAGOH (基因名), Protein mago nashi homolog (蛋白名), MGN_HUMAN.
产品名称:

Human MAGOH/ Protein mago nashi homolog Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

MAGOHA

序列号:
P61326
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human MAGOH Protein
×
Human MAGOH Protein
邮箱 *
消息 *
Please 登录.
产品说明书
说明书: 下载说明书
MSDS: MSDS


基因位点
Cytogenetic band: 1p32.3 by HGNC 1p32.3 by Entrez Gene 1p32.3 by Ensembl
MAGOH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Heterodimer with RBM8A. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A. Interacts with PYM1; the interaction is direct and dissociates the EJC from spliced mRNAs. Identified in the spliceosome C complex.


功能:
Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly.


亚细胞位置:
Nucleus Nucleus speckle Cytoplasm Detected in granule-like structures in the dendroplasm (By similarity). Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles.


该产品尚未在任何出版物中被引用。

[1].
"The mammalian homologue of mago nashi encodes a serum-inducible protein."

[2].
"MAGOH interacts with a novel RNA-binding protein."

[3].
"Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulators."

[4].
"Disassembly of exon junction complexes by PYM."

[5].
"PYM binds the cytoplasmic exon-junction complex and ribosomes to enhance translation of spliced mRNAs."

[6].
"The DNA sequence and biological annotation of human chromosome 1."

[7].
"The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA."

[8].
"Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA."

[9].
"The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity."

[10].
"Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements."
关闭
Sample Data
关闭
Sample Data
关闭
Sample Data
用户中心 close
购物车 close
我的收藏 close
我的足迹 close
清除
产品对比 close
用户中心
购物车
我的收藏
我的足迹
产品对比
回到顶部
消息
close_message
产品名称 *
邮箱 *
消息 *
通知
new 留 言
规格 数量 单价 (¥) 小计 1 (¥)
小计 2:
triangle
规格 数量 单价 (¥)
你想做我们的代理并得到更低的折扣吗?
请联系我们:
电话:027-59234612(+86)
传真:027-59234610(+86)
邮箱:sales@eiaab.com