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MFN2 (基因名), Mitofusin-2 (蛋白名), MFN2_HUMAN.
产品名称:

Human MFN2/ Mitofusin-2 Recombinant Protein
Mitofusin-2

货号:

R15285h

商标:
EIAab®
监管等级:
别名:

Transmembrane GTPase MFN2, CPRP1, KIAA0214

序列号:
O95140
来源:
E.coli
种属:
Human
标签:
His
序列:
341-590aa
预估分子量:
27.5 kDa (monomer)
纯度:
Greater than 90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Neurosciences
Human MFN2 Protein
规格 & 价格: cart
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Human MFN2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Human MFN2 Protein
Recombinant human MFN2 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 1p36.22 by HGNC 1p36.22 by Entrez Gene 1p36.22 by Ensembl
MFN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Forms homomultimers and heteromultimers with MFN1 (By similarity). Oligomerization is essential for mitochondrion fusion (Probable). Interacts with VAT1 (By similarity). Interacts with STOML2; may form heterooligomers (PubMed:17121834). Interacts (phosphorylated) with PARK2 (PubMed:23620051). Interacts with EIF2AK3.


功能:
Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:11181170, PubMed:11950885, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:28114303). Overexpression induces the formation of mitochondrial networks (PubMed:28114303). Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (Probable). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (By similarity). Plays an important role in the regulation of vascular smooth muscle cell proliferation (By similarity). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) (PubMed:23620051). Is required for PARK2 recruitment to dysfunctional mitochondria (PubMed:23620051). Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress (By similarity). Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions.


亚细胞位置:
Mitochondrion outer membrane Multi-pass membrane protein Colocalizes with BAX during apoptosis.


该产品尚未在任何出版物中被引用。

[1].
"MFN2 point mutations occur in 3.4% of Charcot-Marie-Tooth families. An investigation of 232 Norwegian CMT families."

[2].
"Control of mitochondrial morphology by a human mitofusin."

[3].
"Evaluation of nine candidate genes in patients with normal tension glaucoma: a case control study."

[4].
"Genotype-phenotype correlations in Charcot-Marie-Tooth disease type 2 caused by mitofusin 2 mutations."

[5].
"Severe early-onset axonal neuropathy with homozygous and compound heterozygous MFN2 mutations."

[6].
"Identification of a novel mitochondrial complex containing mitofusin 2 and stomatin-like protein 2."

[7].
"Charcot-Marie-Tooth neuropathy type 2A: novel mutations in the mitofusin 2 gene (MFN2)."

[8].
"Axonal neuropathy with optic atrophy is caused by mutations in mitofusin 2."

[9].
"Mitochondrial GTPase mitofusin 2 mutation in Charcot-Marie-Tooth neuropathy type 2A."

[10].
"Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity."
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