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MFN1 (基因名), Mitofusin-1 (蛋白名), MFN1_HUMAN.
产品名称:

Human MFN1/ Mitofusin-1 Recombinant Protein
Mitofusin-1

货号:

R15253h

商标:
EIAab®
监管等级:
别名:

Fzo homolog, Transmembrane GTPase MFN1

序列号:
Q8IWA4
来源:
E.coli
种属:
Human
标签:
His
序列:
2-77aa
预估分子量:
8.36 kDa (monomer)
纯度:
Greater than 95% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Neurosciences
  • Human MFN1 Protein
  • Human MFN1 Protein
  • Human MFN1 Protein
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Human MFN1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


R&D 技术数据
Human MFN1 Protein
The PCR product of human MFN1 gene was determined by 1% Agarose stained with EB.
Human MFN1 Protein
Recombinant human MFN1 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 3q26.33 by HGNC 3q26.33 by Entrez Gene 3q26.33 by Ensembl
MFN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homodimer, also in the absence of bound GTP (PubMed:27920125, PubMed:28114303). Forms higher oligomers in the presence of a transition state GTP analog (PubMed:28114303). Forms homomultimers and heteromultimers with MFN2 (By similarity). Oligomerization is essential for mitochondrion fusion (PubMed:27920125, PubMed:28114303). Component of a high molecular weight multiprotein complex (PubMed:12759376). Interacts with VAT1.


功能:
Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12475957, PubMed:12759376, PubMed:27920125, PubMed:28114303). Membrane clustering requires GTPase activity (PubMed:27920125). It may involve a major rearrangement of the coiled coil domains (PubMed:27920125, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:12475957, PubMed:12759376). Overexpression induces the formation of mitochondrial networks (in vitro) (PubMed:12759376). Has low GTPase activity (PubMed:27920125, PubMed:28114303).


亚细胞位置:
Isoform 2 Cytoplasm


该产品尚未在任何出版物中被引用。

[1].
"Control of mitochondrial morphology by a human mitofusin."

[2].
"Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1."

[3].
"Evaluation of nine candidate genes in patients with normal tension glaucoma: a case control study."

[4].
"Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells."

[5].
"Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins."

[6].
"MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion."

[7].
"Structures of human mitofusin 1 provide insight into mitochondrial tethering."

[8].
"Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression."

[9].
"Mitofusins 1/2 and ERRalpha expression are increased in human skeletal muscle after physical exercise."

[10].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
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