METRNL (基因名), Meteorin-like protein (蛋白名), METRL_HUMAN.
Human METRNL/ Meteorin-like protein Recombinant Protein
29.26 kDa (monomer)
Greater than 95% by SDS-PAGE
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50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
Store at -20°C. (Avoid repeated freezing and thawing.)
The PCR product of human METRNL gene was determined by 1% Agarose stained with EB.
Recombinant human METRNL protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures.
MRGAARAAWG | RAGQPWPRPP | APGPPPPPLP | LLLLLLAGLL | GGAGAQYSSD |
RCSWKGSGLT | HEAHRKEVEQ | VYLRCAAGAV | EWMYPTGALI | VNLRPNTFSP |
ARHLTVCIRS | FTDSSGANIY | LEKTGELRLL | VPDGDGRPGR | VQCFGLEQGG |
LFVEATPQQD | IGRRTTGFQY | ELVRRHRASD | LHELSAPCRP | CSDTEVLLAV |
CTSDFAVRGS | IQQVTHEPER | QDSAIHLRVS | RLYRQKSRVF | EPVPEGDGHW |
QGRVRTLLEC | GVRPGHGDFL | FTGHMHFGEA | RLGCAPRFKD | FQRMYRDAQE |
RGLNPCEVGT | D
"Subfatin is a novel adipokine and unlike Meteorin in adipose and brain expression."
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
"METRNL decreases during adipogenesis and inhibits adipocyte differentiation leading to adipocyte hypertrophy in humans."
"Architecture of the human interactome defines protein communities and disease networks."
"Meteorin-Like Shows Unique Expression Pattern in Bone and Its Overexpression Inhibits Osteoblast Differentiation."
"Adipocyte Metrnl Antagonizes Insulin Resistance Through PPARγ Signaling."
"A human interactome in three quantitative dimensions organized by stoichiometries and abundances."
"Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis."
"Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)."
"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
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