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METTL16 (基因名), RNA N6-adenosine-methyltransferase METTL16 (蛋白名), MET16_HUMAN.
产品名称:

Human METTL16/ RNA N6-adenosine-methyltransferase METTL16 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Methyltransferase 10 domain-containing protein, Methyltransferase-like protein 16, N6-adenosine-methyltransferase METTL16, U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase, METT10D

序列号:
Q86W50
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human METTL16 Protein
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Human METTL16 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


基因位点
Cytogenetic band: 17p13.3 by HGNC 17p13.3 by Entrez Gene 17p13.3 by Ensembl
METTL16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with MEPCE (PubMed:29051200). Interacts with LARP7 (PubMed:29051200).


功能:
RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts (PubMed:28525753, PubMed:30197299, PubMed:30197297). Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs) (PubMed:28525753). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure (PubMed:28525753, PubMed:30197299, PubMed:30197297). Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing and/or stability of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, impairing MAT2A expression (PubMed:28525753). In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A (PubMed:28525753). In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs (PubMed:28525753, PubMed:29051200). Also able to bind various lncRNAs (PubMed:29051200). Specifically binds the 3'-end of the MALAT1 long non-coding RNA (PubMed:27872311).


亚细胞位置:
Nucleus


该产品尚未在任何出版物中被引用。

[1].
"The U6 snRNA m6A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention."

[2].
"Human METTL16 is a N6-methyladenosine (m6A) methyltransferase that targets pre-mRNAs and various non-coding RNAs."

[3].
"Methyltransferase-like protein 16 binds the 3'-terminal triple helix of MALAT1 long noncoding RNA."

[4].
"The ybiN gene of Escherichia coli encodes adenine-N6 methyltransferase specific for modification of A1618 of 23 S ribosomal RNA, a methylated residue located close to the ribosomal exit tunnel."

[5].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."

[6].
"Architecture of the human interactome defines protein communities and disease networks."

[7].
"S-Adenosylmethionine Synthesis Is Regulated by Selective N6-Adenosine Methylation and mRNA Degradation Involving METTL16 and YTHDC1."

[8].
"Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation."

[9].
"The BioPlex Network: A Systematic Exploration of the Human Interactome."

[10].
"Panorama of ancient metazoan macromolecular complexes."
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