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首页  >  重组蛋白  >  Human ACTN4 Recombinant Protein
ACTN4 (基因名), Alpha-actinin-4 (蛋白名), ACTN4_HUMAN.
产品名称:

Human ACTN4/ Alpha-actinin-4 Recombinant Protein
α辅肌动蛋白4

货号:

R1460h

商标:
EIAab®
监管等级:
别名:

Non-muscle alpha-actinin 4

序列号:
O43707
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Epigenetics
Human ACTN4 Protein
规格 & 价格: cart
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Human ACTN4 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 19q13.2 by HGNC 19q13.2 by Entrez Gene 19q13.2 by Ensembl
ACTN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homodimer; antiparallel (By similarity). Binds TRIM3 at the N-terminus (By similarity). Interacts with MICALL2 (preferentially in opened conformation); stimulated by RAB13 activation (By similarity). Identified in a complex with CASK, IQGAP1, MAGI2, NPHS1, SPTAN1 and SPTBN1 (By similarity). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Component of the CART complex, at least composed of ACTN4, HGS/HRS, MYO5B and TRIM3. Interacts with BAIAP1 and PDLIM2. Interacts with PPARG and RARA. Binds to VCL; this interaction triggers VCL conformational changes (PubMed:15988023).


功能:
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778).


亚细胞位置:
Nucleus Cytoplasm Cell junction Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Colocalizes with actin stress fibers. Nuclear translocation can be induced by the PI3 kinase inhibitor wortmannin or by cytochalasin D. Exclusively localized in the nucleus in a limited number of cell lines (breast cancer cell line MCF-7, oral floor cancer IMC-2, and bladder cancer KU-7).


该产品尚未在任何出版物中被引用。

[1].
"Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis."

[2].
"ACTN4 gene mutations and single nucleotide polymorphisms in idiopathic focal segmental glomerulosclerosis."

[3].
"Association analysis of podocyte slit diaphragm genes as candidates for diabetic nephropathy."

[4].
"Crystal structure of the actin-binding domain of alpha-actinin-4 Lys255Glu mutant implicated in focal segmental glomerulosclerosis."

[5].
"Familial focal segmental glomerulosclerosis associated with an ACTN4 mutation and paternal germline mosaicism."
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