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首页  >  重组蛋白  >  Human ACTN1 Recombinant Protein
ACTN1 (基因名), Alpha-actinin-1 (蛋白名), ACTN1_HUMAN.
产品名称:

Human ACTN1/ Alpha-actinin-1 Recombinant Protein
Alpha-actinin-1

货号:

R0376h

商标:
EIAab®
监管等级:
别名:

Alpha-actinin cytoskeletal isoform, F-actin cross-linking protein, Non-muscle alpha-actinin-1

序列号:
P12814
来源:
E.coli
种属:
Human
标签:
His
序列:
1-240aa
预估分子量:
26.4 kDa (monomer)
纯度:
Greater than 90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Human ACTN1 Protein
规格 & 价格: cart
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Human ACTN1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 14q24.1 by HGNC 14q24.1 by Entrez Gene 14q24.1 by Ensembl
ACTN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homodimer; antiparallel. Interacts with DDN, MYOZ2, PDLIM2, TTID and LPP. Interacts with PSD. Interacts with MICALL2 (By similarity). Interacts with DNM2 and CTTN.


功能:
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.


亚细胞位置:
Cytoplasm Cytoskeleton Cytoplasm Myofibril Sarcomere Z line Cell membrane Cell junction Cell projection Ruffle Colocalizes with MYOZ2 and PPP3CA at the Z-line of heart and skeletal muscle. Colocalizes with PSD in membrane ruffles and central reticular structures (By similarity).


该产品尚未在任何出版物中被引用。

[1].
"Postsynaptic recruitment of Dendrin depends on both dendritic mRNA transport and synaptic anchoring."

[2].
"Cloning and chromosomal localization of the human cytoskeletal alpha-actinin gene reveals linkage to the beta-spectrin gene."

[3].
"A missense mutation in the alpha-actinin 1 gene (ACTN1) is the cause of autosomal dominant macrothrombocytopenia in a large French family."

[4].
"ACTN1 mutations cause congenital macrothrombocytopenia."

[5].
"Alpha-actinin 1 and alpha-actinin 4: contrasting roles in the survival, motility, and RhoA signaling of astrocytoma cells."

[6].
"Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia."

[7].
"Genome-wide and candidate gene association study of cigarette smoking behaviors."

[8].
"Isoform-specific contributions of alpha-actinin to glioma cell mechanobiology."

[9].
"Cathepsin X cleaves the beta2 cytoplasmic tail of LFA-1 inducing the intermediate affinity form of LFA-1 and alpha-actinin-1 binding."

[10].
"Mactinin, a fragment of cytoskeletal alpha-actinin, is a novel inducer of heat shock protein (Hsp)-90 mediated monocyte activation."
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