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首页  >  重组蛋白  >  Human ACMSD Recombinant Protein
ACMSD (基因名), 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (蛋白名), ACMSD_HUMAN.
产品名称:

Human ACMSD/ 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase Recombinant Protein
2-amino-3-carboxymuconate-6-semialdehyde脱羧酶

货号:

R15399h

商标:
EIAab®
监管等级:
别名:

Picolinate carboxylase

序列号:
Q8TDX5
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human ACMSD Protein
规格 & 价格: cart
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Human ACMSD Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 2q21.3 by HGNC 2q21.3 by Entrez Gene 2q21.3 by Ensembl
ACMSD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Monomer.


功能:
Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.


亚细胞位置:
N/A


该产品尚未在任何出版物中被引用。

[1].
"Identification and expression of a cDNA encoding human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD). A key enzyme for the tryptophan-niacine pathway and "quinolinate hypothesis"."

[2].
"The crystal structure of human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase in complex with 1,3-dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis."

[3].
"Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies."

[4].
"Tissue expression and biochemical characterization of human 2-amino 3-carboxymuconate 6-semialdehyde decarboxylase, a key enzyme in tryptophan catabolism."

[5].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[6].
"Architecture of the human interactome defines protein communities and disease networks."

[7].
"Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing."

[8].
"An enzyme in the kynurenine pathway that governs vulnerability to suicidal behavior by regulating excitotoxicity and neuroinflammation."

[9].
"Human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD): a structural and mechanistic unveiling."

[10].
"An atlas of genetic influences on human blood metabolites."
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