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首页  >  重组蛋白  >  Human CHRM2 Recombinant Protein
CHRM2 (基因名), Muscarinic acetylcholine receptor M2 (蛋白名), ACM2_HUMAN.
产品名称:

Human CHRM2/ Muscarinic acetylcholine receptor M2 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
序列号:
P08172
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Neurosciences
Human CHRM2 Protein
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Human CHRM2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


基因位点
Cytogenetic band: 7q33 by HGNC 7q33 by Entrez Gene 7q33 by Ensembl
CHRM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with ARRB1 and ARRB2. Interacts with RACK1; the interaction regulates CHRM2 internalization.


功能:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.


亚细胞位置:
Cell membrane Multi-pass membrane protein Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Phosphorylation in response to agonist binding promotes receptor internalization.


该产品尚未在任何出版物中被引用。

[1].
"Association of a variant in the muscarinic acetylcholine receptor 2 gene (CHRM2) with nicotine addiction."

[2].
"No association between Cholinergic Muscarinic Receptor 2 (CHRM2) genetic variation and cognitive abilities in three independent samples."

[3].
"Association of CHRM2 with IQ: converging evidence for a gene influencing intelligence."

[4].
"Down-regulation of muscarinic acetylcholine receptor M2 adversely affects the expression of Alzheimer's disease-relevant genes and proteins."

[5].
"CHRM2 gene predisposes to alcohol dependence, drug dependence and affective disorders: results from an extended case-control structured association study."
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