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首页  >  重组蛋白  >  Human ACIN1 Recombinant Protein
ACIN1 (基因名), Apoptotic chromatin condensation inducer in the nucleus (蛋白名), ACINU_HUMAN.
产品名称:

Human ACIN1/ Apoptotic chromatin condensation inducer in the nucleus Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Acinus, ACINUS, KIAA0670

序列号:
Q9UKV3
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Human ACIN1 Protein
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Human ACIN1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


基因位点
Cytogenetic band: 14q11.2 by HGNC 14q11.2 by Entrez Gene 14q11.2 by Ensembl
ACIN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Found in a mRNA splicing-dependent exon junction complex (EJC). Component of the heterotrimeric ASAP (apoptosis- and splicing-associated protein) complexes consisting of RNPS1, SAP18 and different isoforms of ACIN1; the association of SAP18 seems to require a preformed RNPS1:ACIN1 complex. Interacts with API5. Interacts with SRPK2 in a phosphorylation-dependent manner.


功能:
Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells.


亚细胞位置:
Nucleus Nucleus speckle Nucleus Nucleoplasm Phosphorylation on Ser-1180 by SRPK2 redistributes it from the nuclear speckles to the nucleoplasm.


该产品尚未在任何出版物中被引用。

[1].
"Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation."

[2].
"The antiapoptotic protein AAC-11 interacts with and regulates Acinus-mediated DNA fragmentation."

[3].
"Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core."

[4].
"ASAP, a novel protein complex involved in RNA processing and apoptosis."

[5].
"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."

[6].
"The structure of the ASAP core complex reveals the existence of a Pinin-containing PSAP complex."

[7].
"Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study."

[8].
"Human SAP18 mediates assembly of a splicing regulatory multiprotein complex via its ubiquitin-like fold."

[9].
"NGF inhibits human leukemia proliferation by downregulating cyclin A1 expression through promoting acinus/CtBP2 association."

[10].
"A critical role for AKT activation in protecting cells from ionizing radiation-induced apoptosis and the regulation of acinus gene expression."
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