ACIN1 (基因名), Apoptotic chromatin condensation inducer in the nucleus (蛋白名), ACINU_HUMAN.
Human ACIN1/ Apoptotic chromatin condensation inducer in the nucleus Recombinant Protein
Acinus, ACINUS, KIAA0670
>90% by SDS-PAGE
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Found in a mRNA splicing-dependent exon junction complex (EJC). Component of the heterotrimeric ASAP (apoptosis- and splicing-associated protein) complexes consisting of RNPS1, SAP18 and different isoforms of ACIN1; the association of SAP18 seems to require a preformed RNPS1:ACIN1 complex. Interacts with API5. Interacts with SRPK2 in a phosphorylation-dependent manner.
Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells.
Nucleus Nucleus speckle Nucleus Nucleoplasm Phosphorylation on Ser-1180 by SRPK2 redistributes it from the nuclear speckles to the nucleoplasm.
MWRRKHPRTS | GGTRGVLSGN | RGVEYGSGRG | HLGTFEGRWR | KLPKMPEAVG |
TDPSTSRKMA | ELEEVTLDGK | PLQALRVTDL | KAALEQRGLA | KSGQKSALVK |
RLKGALMLEN | LQKHSTPHAA | FQPNSQIGEE | MSQNSFIKQY | LEKQQELLRQ |
RLEREAREAA | ELEEASAESE | DEMIHPEGVA | SLLPPDFQSS | LERPELELSR |
HSPRKSSSIS | EEKGDSDDEK | PRKGERRSSR | VRQARAAKLS | EGSQPAEEEE |
DQETPSRNLR | VRADRNLKTE | EEEEEEEEEE | EDDEEEEGDD | EGQKSREAPI |
LKEFKEEGEE | IPRVKPEEMM | DERPKTRSQE | QEVLERGGRF | TRSQEEARKS |
HLARQQQEKE | MKTTSPLEEE | EREIKSSQGL | KEKSKSPSPP | RLTEDRKKAS |
LVALPEQTAS | EEETPPPLLT | KEASSPPPHP | QLHSEEEIEP | MEGPAPAVLI |
QLSPPNTDAD | TRELLVSQHT | VQLVGGLSPL | SSPSDTKAES | PAEKVPEESV |
LPLVQKSTLA | DYSAQKDLEP | ESDRSAQPLP | LKIEELALAK | GITEECLKQP |
SLEQKEGRRA | SHTLLPSHRL | KQSADSSSSR | SSSSSSSSSR | SRSRSPDSSG |
SRSHSPLRSK | QRDVAQARTH | ANPRGRPKMG | SRSTSESRSR | SRSRSRSASS |
NSRKSLSPGV | SRDSSTSYTE | TKDPSSGQEV | ATPPVPQLQV | CEPKERTSTS |
SSSVQARRLS | QPESAEKHVT | QRLQPERGSP | KKCEAEEAEP | PAATQPQTSE |
TQTSHLPESE | RIHHTVEEKE | EVTMDTSENR | PENDVPEPPM | PIADQVSNDD |
RPEGSVEDEE | KKESSLPKSF | KRKISVVSAT | KGVPAGNSDT | EGGQPGRKRR |
WGASTATTQK | KPSISITTES | LKSLIPDIKP | LAGQEAVVDL | HADDSRISED |
ETERNGDDGT | HDKGLKICRT | VTQVVPAEGQ | ENGQREEEEE | EKEPEAEPPV |
PPQVSVEVAL | PPPAEHEVKK | VTLGDTLTRR | SISQQKSGVS | ITIDDPVRTA |
QVPSPPRGKI | SNIVHISNLV | RPFTLGQLKE | LLGRTGTLVE | EAFWIDKIKS |
HCFVTYSTVE | EAVATRTALH | GVKWPQSNPK | FLCADYAEQD | ELDYHRGLLV |
DRPSETKTEE | QGIPRPLHPP | PPPPVQPPQH | PRAEQREQER | AVREQWAERE |
REMERRERTR | SEREWDRDKV | REGPRSRSRS | RDRRRKERAK | SKEKKSEKKE |
KAQEEPPAKL | LDDLFRKTKA | APCIYWLPLT | DSQIVQKEAE | RAERAKEREK |
RRKEQEEEEQ | KEREKEAERE | RNRQLEREKR | REHSRERDRE | RERERERDRG |
DRDRDRERDR | ERGRERDRRD | TKRHSRSRSR | STPVRDRGGR | R
"Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation."
"The antiapoptotic protein AAC-11 interacts with and regulates Acinus-mediated DNA fragmentation."
"Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core."
"ASAP, a novel protein complex involved in RNA processing and apoptosis."
"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
"The structure of the ASAP core complex reveals the existence of a Pinin-containing PSAP complex."
"Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study."
"Human SAP18 mediates assembly of a splicing regulatory multiprotein complex via its ubiquitin-like fold."
"NGF inhibits human leukemia proliferation by downregulating cyclin A1 expression through promoting acinus/CtBP2 association."
"A critical role for AKT activation in protecting cells from ionizing radiation-induced apoptosis and the regulation of acinus gene expression."
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