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首页  >  重组蛋白  >  Human CHRNB4 Recombinant Protein
CHRNB4 (基因名), Neuronal acetylcholine receptor subunit beta-4 (蛋白名), ACHB4_HUMAN.
产品名称:

Human CHRNB4/ Neuronal acetylcholine receptor subunit beta-4 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
序列号:
P30926
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Neurosciences
Human CHRNB4 Protein
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Human CHRNB4 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


基因位点
Cytogenetic band: 15q25.1 by HGNC 15q25.1 by Entrez Gene 15q25.1 by Ensembl
CHRNB4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Neuronal AChR is composed of two different types of subunits: alpha and beta. Beta-4 subunit can be combined to alpha-2, alpha-3 or alpha-4 to give rise to functional receptors. Interacts with RIC3; which is required for proper folding and assembly (PubMed:16120769). Interacts with LYPD6 (PubMed:27344019). The pentamer alpha3-beta-4 interacts with the conotoxin BuIA.


功能:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.


亚细胞位置:
Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein


该产品尚未在任何出版物中被引用。

[1].
"Rare missense variants of neuronal nicotinic acetylcholine receptor altering receptor function are associated with sporadic amyotrophic lateral sclerosis."

[2].
"Transcription factors NF-Y and Sp1 are important determinants of the promoter activity of the bovine and human neuronal nicotinic receptor beta 4 subunit genes."

[3].
"Functional interaction between Lypd6 and nicotinic acetylcholine receptors."

[4].
"GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease."

[5].
"Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans."

[6].
"Human variation in alcohol response is influenced by variation in neuronal signaling genes."

[7].
"Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes."

[8].
"Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study."

[9].
"Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans."

[10].
"Fine mapping of chromosome 15q25.1 lung cancer susceptibility in African-Americans."
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