CHRNB2 (基因名), Neuronal acetylcholine receptor subunit beta-2 (蛋白名), ACHB2_HUMAN.
Human CHRNB2/ Neuronal acetylcholine receptor subunit beta-2 Recombinant Protein
>90% by SDS-PAGE
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50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
Store at -20°C. (Avoid repeated freezing and thawing.)
Neuronal AChR is composed of two different types of subunits: alpha and beta. Beta-2 subunit can be combined to alpha-2, alpha-3 or alpha-4 to give rise to functional receptors, complexes with beta-2 may be heteropentamers. Alpha-2/4:beta-2 nAChR complexes are proposed to exist in two subtypes: LS (low agonist sensitivity) with a (alpha-2/4)3:(beta-2)2 and HS (high agonist sensitivity) with a (alpha-2/4)2:(beta-2)3 stoichiometry; the subtypes differ in their subunit binding interfaces which are involved in ligand binding (PubMed:27493220, PubMed:22361591). Interacts with RIC3; which is required for proper folding and assembly (PubMed:16120769). Interacts with LYPD6 (PubMed:27344019). The pentamer alpha3-beta-2 interacts with the conotoxin BuIA and the conotoxin MII.
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions.
Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein
MARRCGPVAL | LLGFGLLRLC | SGVWGTDTEE | RLVEHLLDPS | RYNKLIRPAT |
NGSELVTVQL | MVSLAQLISV | HEREQIMTTN | VWLTQEWEDY | RLTWKPEEFD |
NMKKVRLPSK | HIWLPDVVLY | NNADGMYEVS | FYSNAVVSYD | GSIFWLPPAI |
YKSACKIEVK | HFPFDQQNCT | MKFRSWTYDR | TEIDLVLKSE | VASLDDFTPS |
GEWDIVALPG | RRNENPDDST | YVDITYDFII | RRKPLFYTIN | LIIPCVLITS |
LAILVFYLPS | DCGEKMTLCI | SVLLALTVFL | LLISKIVPPT | SLDVPLVGKY |
LMFTMVLVTF | SIVTSVCVLN | VHHRSPTTHT | MAPWVKVVFL | EKLPALLFMQ |
QPRHHCARQR | LRLRRRQRER | EGAGALFFRE | APGADSCTCF | VNRASVQGLA |
GAFGAEPAPV | AGPGRSGEPC | GCGLREAVDG | VRFIADHMRS | EDDDQSVSED |
WKYVAMVIDR | LFLWIFVFVC | VFGTIGMFLQ | PLFQNYTTTT | FLHSDHSAPS |
"Genetic and functional analysis of single nucleotide polymorphisms in the beta2-neuronal nicotinic acetylcholine receptor gene (CHRNB2)."
"CHRNA2 mutations are rare in the NFLE population: evaluation of a large cohort of Italian patients."
"A novel mutation of the nicotinic acetylcholine receptor gene CHRNA4 in sporadic nocturnal frontal lobe epilepsy."
"Association of genes coding for the alpha-4, alpha-5, beta-2 and beta-3 subunits of nicotinic receptors with cigarette smoking and nicotine dependence."
"Assessment of Alzheimer's disease case-control associations using family-based methods."
"Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function."
"Genetic association analysis of tagging SNPs in alpha4 and beta2 subunits of neuronal nicotinic acetylcholine receptor genes (CHRNA4 and CHRNB2) with schizophrenia in the Japanese population."
"Alpha4 and beta2 subunits of neuronal nicotinic acetylcholine receptor genes are not associated with methamphetamine-use disorder in the Japanese population."
"Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database."
"Association of idiopathic generalized epilepsy with polymorphisms in the neuronal nicotinic acetylcholine receptor subunits."
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