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首页  >  重组蛋白  >  Human CHRNA4 Recombinant Protein
CHRNA4 (基因名), Neuronal acetylcholine receptor subunit alpha-4 (蛋白名), ACHA4_HUMAN.
产品名称:

Human CHRNA4/ Neuronal acetylcholine receptor subunit alpha-4 Recombinant Protein
神经元乙酰胆碱受体亚单位α -4

货号:

R1913h

商标:
EIAab®
监管等级:
别名:

NACRA4

序列号:
P43681
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Neurosciences
Human CHRNA4 Protein
规格 & 价格: cart
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Human CHRNA4 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 20q13.33 by HGNC 20q13.33 by Entrez Gene 20q13.33 by Ensembl
CHRNA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Neuronal AChR is composed of two different types of subunits: alpha and beta. Alpha-4 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors, complexes with beta-2 may be heteropentamers (PubMed:22361591). Interacts with RIC3; which is required for proper folding and assembly (PubMed:16120769). Interacts with LYPD6 (PubMed:27344019).


功能:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions.


亚细胞位置:
Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein Cell membrane Lipid-anchor


该产品尚未在任何出版物中被引用。

[1].
"CHRNA2 mutations are rare in the NFLE population: evaluation of a large cohort of Italian patients."

[2].
"A novel mutation of the nicotinic acetylcholine receptor gene CHRNA4 in sporadic nocturnal frontal lobe epilepsy."

[3].
"Association of genes coding for the alpha-4, alpha-5, beta-2 and beta-3 subunits of nicotinic receptors with cigarette smoking and nicotine dependence."

[4].
"Rare missense variants of neuronal nicotinic acetylcholine receptor altering receptor function are associated with sporadic amyotrophic lateral sclerosis."

[5].
"Association of nAChR gene haplotypes with heavy alcohol use and body mass."

[6].
"Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene."

[7].
"The 1674+11C>T polymorphism of CHRNA4 is associated with juvenile myoclonic epilepsy."

[8].
"Association of nicotinic acetylcholine receptor subunit alpha 4 polymorphisms with nicotine dependence in 5500 Germans."

[9].
"Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function."

[10].
"Alpha4 and beta2 subunits of neuronal nicotinic acetylcholine receptor genes are not associated with methamphetamine-use disorder in the Japanese population."
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