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CHRNA3 (基因名), Neuronal acetylcholine receptor subunit alpha-3 (蛋白名), ACHA3_HUMAN.
产品名称:

Human CHRNA3/ Neuronal acetylcholine receptor subunit alpha-3 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

NACHRA3

序列号:
P32297
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Neurosciences
Human CHRNA3 Protein
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Human CHRNA3 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


基因位点
Cytogenetic band: 15q25.1 by HGNC 15q25.1 by Entrez Gene 15q25.1 by Ensembl
CHRNA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Neuronal AChR is composed of two different types of subunits: alpha and beta. Alpha-3 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors. Interacts with RIC3; which is required for proper folding and assembly (PubMed:16120769). Interacts with LYPD6 (PubMed:27344019).


功能:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.


亚细胞位置:
Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein


该产品尚未在任何出版物中被引用。

[1].
"Sensorimotor gating is associated with CHRNA3 polymorphisms in schizophrenia and healthy volunteers."

[2].
"Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans."

[3].
"Rare missense variants of neuronal nicotinic acetylcholine receptor altering receptor function are associated with sporadic amyotrophic lateral sclerosis."

[4].
"Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1."

[5].
"A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25."

[6].
"A variant associated with nicotine dependence, lung cancer and peripheral arterial disease."

[7].
"Association of novel and established polymorphisms in neuronal nicotinic acetylcholine receptors with sporadic Alzheimer's disease."

[8].
"The structures of the human neuronal nicotinic acetylcholine receptor beta2- and alpha3-subunit genes (CHRNB2 and CHRNA3)."

[9].
"Functional interaction between Lypd6 and nicotinic acetylcholine receptors."

[10].
"Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function."
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