本公司产品仅供科研使用,不用于人体及临床诊断。
027-59234612(+86)
我的积分
注册  /  登录
EIAab
首页  >  重组蛋白  >  Human ACER2 Recombinant Protein
ACER2 (基因名), Alkaline ceramidase 2 (蛋白名), ACER2_HUMAN.
产品名称:

Human ACER2/ Alkaline ceramidase 2 Recombinant Protein

货号:

R11204h

商标:
EIAab®
监管等级:
别名:

Acylsphingosine deacylase 3-like, N-acylsphingosine amidohydrolase 3-like, PP11646, AlkCDase 2, ASAH3L

序列号:
Q5QJU3
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human ACER2 Protein
规格 & 价格: cart
×
Human ACER2 Protein
邮箱 *
消息 *
Please 登录.
产品说明书
说明书: 下载说明书
MSDS: MSDS


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 9p22.1 by HGNC 9p22.1 by Entrez Gene 9p22.1 by Ensembl
ACER2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
N/A


功能:
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. Unsaturated long-chain ceramides are the best substrates, saturated long-chain ceramides and unsaturated very long-chain ceramides are good substrates, whereas saturated very long-chain ceramides and short-chain ceramides were poor substrates. The substrate preference is D-erythro-C(18:1)-, C(20:1)-, C(20:4)-ceramide > D-erythro-C(16:0)-, C(18:0), C(20:0)-ceramide > D-erythro-C(24:1)-ceramide > D-erythro-C(12:0)-ceramide, D-erythro-C(14:0)-ceramides > D-erythro-C(24:0)-ceramide > D-erythro-C(6:0)-ceramide. Inhibits the maturation of protein glycosylation in the Golgi complex, including that of integrin beta-1 (ITGB1) and of LAMP1, by increasing the levels of sphingosine. Inhibits cell adhesion by reducing the level of ITGB1 in the cell surface. May have a role in cell proliferation and apoptosis that seems to depend on the balance between sphingosine and sphingosine-1-phosphate.


亚细胞位置:
Golgi apparatus membrane Multi-pass membrane protein


该产品尚未在任何出版物中被引用。

[1].
"Alkaline ceramidase 2 regulates beta1 integrin maturation and cell adhesion."

[2].
"Substrate specificity, membrane topology, and activity regulation of human alkaline ceramidase 2 (ACER2)."

[3].
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."

[4].
"Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P."

[5].
"DNA sequence and analysis of human chromosome 9."

[6].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[7].
"Large-scale cDNA transfection screening for genes related to cancer development and progression."

[8].
"Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response."

[9].
"Regulation of alkaline ceramidase activity by the c-Src-mediated pathway."

[10].
"Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine mediate the cytotoxicity of N-(4-hydroxyphenyl)retinamide in tumor cells."
关闭
Sample Data
关闭
Sample Data
关闭
Sample Data
用户中心 close
购物车 close
我的收藏 close
我的足迹 close
清除
产品对比 close
用户中心
购物车
我的收藏
我的足迹
产品对比
回到顶部
消息
close_message
产品名称 *
邮箱 *
消息 *
通知
new 留 言
规格 数量 单价 (¥) 小计 1 (¥)
小计 2:
triangle
规格 数量 单价 (¥)
你想做我们的代理并得到更低的折扣吗?
请联系我们:
电话:027-59234612(+86)
传真:027-59234610(+86)
邮箱:sales@eiaab.com