首页 > 重组蛋白 > Human ACD Recombinant Protein

ACD (基因名), Adrenocortical dysplasia protein homolog (蛋白名), ACD_HUMAN.

产品名称:

Human ACD/ Adrenocortical dysplasia protein homolog Recombinant Protein

货号:

商标:

EIAab^®

监管等级:

RUO

别名:

POT1 and TIN2-interacting protein, PIP1, PTOP, TINT1, TPP1

序列号:

Q96AP0

来源:

E.coli

种属:

Human

标签:

His

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

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Human ACD Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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基因位点

Cytogenetic band: 16q22.1 by HGNC 16q22.1 by Entrez Gene 16q22.1 by Ensembl

ACD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Forms heterodimers with POT1. Identified in a complex with POT1 and single-stranded telomeric DNA. Interacts with STN1 and TINF2.

功能:

Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.

亚细胞位置:

Nucleus Chromosome Telomere

数据库链接

UniGene:

Hs.78019

SMR:

Q96AP0

STRING:

9606.ENSP00000377496

KEGG:

hsa:65057

MIM:

609377

Uniprot:

Q96AP0

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序列长度:

544

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

544:

QYEYEPPCTS | LCARVQAVRL | PPQLMAWALH | FLMDAQPGSE | PTPM

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"PTOP interacts with POT1 and regulates its localization to telomeres."

(PMID: 15181449)

[2].

"POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex."

(PMID: 15231715)

[3].

"TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres."

(PMID: 15316005)

[4].

"Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins."

(PMID: 15383534)

[5].

"Inherited bone marrow failure associated with germline mutation of ACD, the gene encoding telomere protein TPP1."

(PMID: 25205116)

[6].

"Genetic variants in eleven telomere-associated genes and the risk of incident cardio/cerebrovascular disease: The Women's Genome Health Study."

(PMID: 20937264)

[7].

"Polymorphisms in telomere-associated genes, breast cancer susceptibility and prognosis."

(PMID: 19766477)

[8].

"OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulation."

(PMID: 19648609)

[9].

"The POT1-TPP1 telomere complex is a telomerase processivity factor."

(PMID: 17237768)

[10].

"Novel polymorphisms and lack of mutations in the ACD gene in patients with ACTH resistance syndromes."

(PMID: 17466001)

[1].

人ACD重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人ACD重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人ACD重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人ACD重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人ACD重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人ACD重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人ACD重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人ACD重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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