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首页  >  重组蛋白  >  Human ACCN2 Recombinant Protein
ACCN2 (基因名), Amiloride-sensitive cation channel 2, neuronal (蛋白名), ACCN2_HUMAN.
产品名称:

Human ACCN2/ Amiloride-sensitive cation channel 2, neuronal Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Acid-sensing ion channel 1, Brain sodium channel 2, ASIC1, BNaC2, ASIC1, BNAC2

序列号:
P78348
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human ACCN2 Protein
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Human ACCN2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


通用注释


亚单元:
Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with STOM and ACCN1 (By similarity). Interacts with PRKCABP.


功能:
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca(2+), Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.


亚细胞位置:
Cell membrane Multi-pass membrane protein Localizes in synaptosomes at dendritic synapses of neurons. Colocalizes with DLG4.


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