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首页  >  重组蛋白  >  Human ABHD12 Recombinant Protein
ABHD12 (基因名), Lysophosphatidylserine lipase ABHD12 (蛋白名), ABD12_HUMAN.
产品名称:

Human ABHD12/ Lysophosphatidylserine lipase ABHD12 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

2-arachidonoylglycerol hydrolase ABHD12, Abhydrolase domain-containing protein 12, Monoacylglycerol lipase ABHD12, Oxidized phosphatidylserine lipase ABHD12, hABHD12, C20orf22

序列号:
Q8N2K0
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human ABHD12 Protein
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Human ABHD12 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


基因位点
Cytogenetic band: 20p11.21 by HGNC 20p11.21 by Entrez Gene 20p11.21 by Ensembl
ABHD12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
N/A


功能:
Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (PubMed:25290914, PubMed:30237167, PubMed:30420694, PubMed:30720278, PubMed:30643283). Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (By similarity). Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal (PubMed:30643283). Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways (PubMed:22969151, PubMed:24027063). Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding (PubMed:30237167).


亚细胞位置:
Endoplasmic reticulum membrane Single-pass membrane protein


该产品尚未在任何出版物中被引用。

[1].
"Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12)."

[2].
"Biochemical and pharmacological characterization of the human lymphocyte antigen B-associated transcript 5 (BAT5/ABHD16A)."

[3].
"Two novel mutations in ABHD12: expansion of the mutation spectrum in PHARC and assessment of their functional effects."

[4].
"Targeted next-generation sequencing identifies a homozygous nonsense mutation in ABHD12, the gene underlying PHARC, in a family clinically diagnosed with Usher syndrome type 3."

[5].
"Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma."
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